CMMB 413 Exam with 100% Correct Answers | Verified | Latest 2024 Version

CMMB 413 Exam with 100% Correct Answers | Verified | Latest 2024 Version Types of DNA Variation - single nucleotide variant (SNV) - small nucleotide insertion/deletion - dynamic mutations - microsatellite - copy number variation (CNV) Single Nucleotide Variants (SNVs) - most common type of sequence variation - >3 000 000 per person - can be benign or disease causing Initiation Codon (Start Codon) AUG (methionine) Stop Codons UGA, UAA, UAG 20 number of amino acids 64 number of different codons SNV Effects - nucleotide substitutions within genes - duplications/deletions Types of Nucleotide Substitutions - silent (synonymous) - missense (non-synonymous) - nonsense - read through Silent/Synonymous Substitutions DNA sequence change doesn't alter the amino acid coded Missense/Non-synonymous Substitution DNS sequence change alters the amino acid coded Nonsense Substitution DNA sequence change results in a stop codon Readthrough/Nonstop Substitution DNA sequence change results in a stop codon loss Frameshift Mutation - results from small duplications/deletions