What are the four phases of pharmacokinetics Correct Answer - Absorption, distribution, metabolism, excretion
Which type of meds takes long to be absorbed? Correct Answer - oral and intradermal/topical
Which type of meds get quickly absorbed? Correct Answer - sublingual and inhaled
which type of medication gets absorbed immediately? Correct Answer - IV meds
what should you teach p/t taking a sublingual medication? Correct Answer - wait for the med to be completely dissolved before eating and drinking
How does distribution occur? Correct Answer - through the use of binding proteins
like albumin
two common side effects of all medications: Correct Answer - GI upset, headache
What is important to note about herbs starting with "G" Correct Answer - they increase the p/t risk for bleeding
what is important to note about medications ending in "MAB" or "MIB" Correct Answer - they're immunosuppressants and increase p/t risk for infection How does metabolism occur? Correct Answer - meds get broken down to their less
active form by enzymes
Where does metabolism primarily occur? Correct Answer - the liver
Why are babies and older p/t at an increased risk of medication toxicity Correct Answer - they both have impaired metabolism
Describe the First Pass Effect Correct Answer - some meds get inactivated when they pass through the liver the first time so you may need to increase the dose to reach a therapeutic effect
Describe excretion Correct Answer - when meds get filtered out through the kidneys
Describe the relationship between impaired kidney function and toxicity Correct Answer - p/t can adequately metabolize or excrete meds so they are at higher risk
What needs to be done for medications with a low therapeutic index? Correct Answer - peak and trough
example of one med that needs a peak and trough Correct Answer - vancomycin
What two characteristics of meds out a p/t at risk for toxicity? Correct Answer - low therapeutic index and long half life
Agonist = Correct Answer - enhances