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Samenvatting labo pathologische anatomie

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May 28, 2024
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Microscopie:
Normaal cervix uitstrijkje:

Squameuze cellen:
- Oppervlakkige squameuze epitheelcellen:
- Veelhoekige intermediaire cellen met veel cytoplasma:
- Parabasale cellen met basofiel cytoplasma en fijn granulair chromatine in grote celkern:
- Basale cellen uit de onderste basale laag → komt zelden voor:

Squameuze metaplastische cellen:
→ epitheelcellen uit de transformatiezone




Glandulaire cellen:




RBC, WBC, Histiocyt en macrofagen:




NILM: (Negatief voor Intra-epitheliale Laesie of Maligniteit)
- Parakeratose = verhoornde oppervlakkige squameuze cellen met een kern
- Metaplasie = vervanging van 1 soort epitheel door een ander epitheel
3 stadia: Reservecelhyperplasie, onrijpe metaplasie en rijpe metaplasie.

, - Specifieke ontsteking: Candida (A), Trichomonas vaginalis (B), Herpes (C), Gardnerella
vaginalis (D)




- Menopauze atrofie = vooral intermediaire en parabasale cellen te zien → cellen die afsterven,
celdood, bovenste cellen verdwijnen bij menopauze




- Wijzigingen in verband met een IUD (spiraaltje)




Afwijkende epitheelcellen:

ASC-US: (Atypical Squamous Cells of Undetermined Significance)
- Plaveiselcellen vh oppervlakkig of intermediair celtype met kernafwijkingen die kunnen wijzen
op een LSIL (laaggradig squameus intraepitheliaal letsel)
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