Hematology AAB MOCK EXAM missed questions and answrs(latest upate)

Monocyte Identify the nucleated blood cell. Lymphocyte Band neutrophil Monocyte Eosinophil Homozygous HbSS A completely sickled cell (drepanocyte) is most commonly seen in which of these conditions? Homozygous HbSS Heterozygous HbSA Double heterozygous HbSC Hb S with beta thalassemia Truly sickled cells are a result of a homozygous HbSS state. Heterozygous HbSA or Sickle cell trait patients typically do not exhibit any red blood cell abnormalities on the peripheral smear. In double heterozygous HbSC, sickle cells are rarely seen on the peripheral smear. Typically more than half the erythrocytes are target cells. Plump sickle forms may also be noted as well. Hb S with beta-thalassemia is characterized by microcytes and 4+ target cells on the peripheral smear. The serum ferritin decreases to between 20 and 50 ng/mL What is a typical finding for determining the endpoint for the initial or iron-depletion phase of treatment for hereditary hemochromatosis (HH)? The serum ferritin decreases to between 20 and 50 ng/mL The hepatic iron index returns to normal The transferrin saturation drops below 20% The serum iron falls to below 35 µg/dL. Mast cell Which of the marrow cells from the list below has highly granular basophilic cytoplasm but does not show nuclear lobules? Macrophage Mast cell lipocyte Osteoblast Hgb A = 60%, Hgb S = 38%, Hgb A2 = 2%, Hgb F = 0% Patients with sickle cell trait commonly have Hgb A values between 40 and 60%, Hgb S values between 20 and 40%, and Hgb A2 values between 2 and 3%. A known sickle cell trait patient has a hemoglobin electrophoresis test performed. Which of the following hemoglobin percentage sets would most closely match this patient's diagnostic state? Hgb A = 90%, Hgb S = 8%, Hgb A2 = 2%, Hgb F = 0% Hgb A = 60%, Hgb S = 38%, Hgb A2 = 2%, Hgb F = 0% Hgb A = 40%, Hgb S = 58%, Hgb A2 = 2%, Hgb F = 0% Hgb A = 25%, Hgb S = 70%, Hgb A2 = 2%, Hgb F = 3% Factor IX Hemophilia B or Christmas disease is the result of a hereditary deficiency in which coagulation factor? Factor X Factor VIII Factor XI Factor IX MCV - hct/RBC x 10 MCH - hb/RBC x 10 MCHC - hb/hct x 100 state the formulas used for calculating the RBC indices. MCV MCH MCHC Hb H inclusions This image depicts a brilliant cresyl blue-stained blood smear. What inclusion bodies are shown in the erythrocyte indicated by the arrow (B)? Howell-Jolly bodies Hb H inclusions Pappenheimer bodies Siderotic granules Left shift The cells included in the composite image were found in the peripheral blood smear of a patient with the following results: total WBC of 21.5 x 109/L. Differential count: metamyelocytes 4 band neutrophils 16 segmented neutrophils 48 monocytes 6 eosinophils 1 basophils 1 lymphocytes 24 This hematologic picture is most consistent with: Leukemoid reaction Chronic myeloid leukemia Left shift Leukoerythroblastosis HbS/HPFH The patient lanes 3 & 4 shows nearly equal bands in the "S" and "F" positions. In HbS/HPFH, there would be two bands on alkaline electrophoresis, one would be in the S position. Hereditary Persistence of Fetal Hemoglobin (HPFH) will result in a band in the F position. This is consistent with HbS/HPFH. In alkaline hemoglobin electrophoresis, the sample is applied closest to the cathode (negatively charged electrode). Once current is applied, the hemoglobins move toward the anode (positively charged electrode). Based on the hemoglobin controls shown in the alkaline electrophoresis, hemoglobin A is the fastest moving hemoglobin and is represented by the band closest to the anode in lanes 1, 2, 5 & 6. Hemoglobin F is the next fastest and is represented by the band second closest to the anode in lanes 2 & 5. Hemoglobin S is next and is represented by the second band in lanes 1 & 6. Hemoglobin C is the slowest he The alkaline hemoglobin electrophoresis pattern shown on the right includes controls for A, S, and C; and A and F above and below the patient results. (NOTE: ASC and AF are labeled for the controls and do not indicate the migration order.) The patient was tested in duplicate, and the results are in lanes 3 and 4. The patient lanes (3 and 4) displayed in these hemoglobin electrophoresis patterns are consistent with what diagnosis? HbSA HbSC HbSD HbS/HPFH Myelophthisic anemia Which of the following is characterized by the bone marrow being invaded by fibrotic, granulomatous, or neoplastic cells? Fanconi anemia Megaloblastic anemia Myelophthisic anemia Diamond-Blackfan anemia Staining cellular components that have an acidic pH such as ribosomes, DNA, and RNA Methylene blue stain works by: Staining cellular components that have a neutral pH, such as neutrophilic granules Staining cellular components that have an acidic pH such as ribosomes, DNA, and RNA Staining cellular components that have a basic pH such as cytoplasmic proteins Staining cellular components regardless of the pH Tartrate-resistant acid phosphatase test Which one of the following is a useful chemical test for the diagnosis of hairy cell leukemia? Peroxidase test Sudan black test Alpha-naphthyl acetate esterase test Tartrate-resistant acid phosphatase test Increased serum ferritin What is a common early laboratory marker of hereditary hemochromatosis (HH)? Increased serum ferritin Decreased serum iron Decreased transferrin saturation Increased hemoglobin Monocyte What type of cell is indicated by the arrow? Monocyte Blast Macrophage Tumor cell Transfusion dimorphism Which of the following conditions/findings is most likely associated with the peripheral blood picture in the photomicrograph? Hereditary spherocytosis Lead poisoning Transfusion dimorphism Folic acid deficiency Decreased RBCs, platelets, and WBCs This photo shows the bone marrow aspirate of a patient with a history of fatigue and petechiae. The CBC from the peripheral blood would confirm: Decreased RBCs, platelets, and WBCs Decreased RBCs Decreased WBCs Decreased platelets Beta, gamma, epsilon Which of the following globin genes are found on Chromosome 11? Beta, gamma, epsilon Beta, epsilon, alpha Gamma, epsilon, zeta Alpha, zeta Basophil Identify the white blood cell seen in this illustration: Myelocyte Neutrophil Eosinophil Basophil Schistocytes What RBC morphology on a Wright-stained smear may indicate the presence of an unstable hemoglobin? Acanthocytes Codocytes