MMSC490 QUESTIONS: FINAL CHP.18

The Bcl-2 family of proteins is divided into three functional groups that contain and share as many as four Bcl-2 homology domains (BH domains). Which of the following is common to all members of the Bcl-2 family? a. BH1 b. BH2 c. BH3 d. BH4 - Answer- BH3 which of the following stem cells have the capacity to give rise to all the differentiated cell types of adult organisms? - Answer- embryonic stem cells Murine embryonic stem cells are grown in the presence of a growth factor. What growth factor is generally used for this? a. VEGF (vascular endothelial growth factor) b. LIF (leukemia inhibitory factor) c. PDGF (platelet-derived growth factor) d. EGF (epidermal growth factor) - Answer- LIF (leukemia inhibitory factor) Which of the following signaling pathways is not important to stem cell physiology? - Answer- Bax Which of the following diseases would not be an ideal target for therapeutic cloning - Answer- HIV Some differentiated cells retain the ability to proliferate as needed to repair damaged tissue throughout the life of an organisms. Which of the following cell types do not retain this unique ability? - Answer- neurons In 2006, Takahshi and Yamanaka demonstrated that somatic cells can be reprogrammed or converted into induced pluripotent stem cells. Subsequent studies in _______ showed that these cells, like embryonicc stem cells, are capable of differentiating into virtually all cells. - Answer- Mice Which of the following transcription factors has the potential to act as an oncogene, resulting in a high risk of cancer? - Answer- c-Myc A major pathway that signals cell survivial and inhibits cell death is the _______ pathway - Answer- PI-3- kinase/ Akt Which of the following cells cannot develop from hematopoietic stem cells - Answer- satellite cells fibroblasts are stimulated to exit G0 and proliferate by ______ growth factor - Answer- platelet