Disorders of Hemostasis - N5315 Advanced Pathophysiology Questions with Complete solutions

A defect in the coagulation process which results in the prolongation of the PT and/or PTT; increases risk of bleeding in most instances Correct Answer-What is a coagulopathy? No Correct Answer-Does a deficiency in Hageman Factor (Factor XII) increase bleeding risk? Joint bleeding; tissue hematomas; large, spontaneous, centrally located Correct Answer-What are the clinical manifestations of a bleed from a coagulopathy? A decrease in the total number of platelets; numerous etiologies Correct Answer-What is a thrombocytopenia? Mucosal bleeding (epistaxis, oral bleeding, GI/GU bleeding in absence of malignancy, hemoptysis, heavy menses); bleeding occurs immediately after a trauma or injury; petechiae may be present Correct Answer-What are the clinical manifestations of a bleed from a thromblocytopenia? An increased number of platelets; can occur due to bone marrow disorders or after a splenectomy Correct Answer-What does thrombocythemia and thrombocytosis both indicate? Term used to describe a low number of platele