Basic & Clinical Pharmacology - Antineoplastic Drugs Exam Questions with 100% Correct Answers Verified | Updated

Basic & Clinical Pharmacology - Antineoplastic Drugs Exam Questions with 100% Correct Answers Verified | Updated What does the body need? - answerBody needs cells to reproduce and grow in an orderly and regulated manner What can unregulated growth have? and lead to what? - answerUnregulated growth can lead to abnormal cell, tissue, and tumor development What is benign? - answernon-cancerous What is malignant? - answercancerous What is antineoplastic drug? - answeragent that counteracts development, growth, or spread of malignant cells What is chemotherapy? - answerthe use of drugs to treat a disease, which is a constatnt growing field Chemotherapy is the use of what? - answerthe use of many old drugs and new drugs When is chemotherapy used? - answerpalliative long-term remission What are cytotoxic medications? - answerEspecially effective for cells that are proliferating In chemotherapy, the dveloping treatments target only cancer cells to do what? - answerReduces host toxicity Improves survival rates In chemotherapy, therapy is personalized for what? - answerUsing pharmacogenomic biomarkers In chemotherapy, many agents are immunosuppressive, which cause what? - answerDecrease production of WBCs and antibodies and reduce inflammation Increased susceptibility to infections How is chemotherapy administered? - answer- Therapy is usually high doses administered on an intermittent schedule - Therapy is individualized and modified based on each patient's response - Combinations often used to minimize resistance Chemotherapy is what? - answerhighly complex In chemotherapy, half of patients receive what? - answerradiation What are types of chemotherapy drugs? - answerantimetabolites alkylating agents mitotic inhibitors (plant alkaloids, taxanes) antitumor antibiotics hormones and hormone modifiers (corticosteroids, antiestrogens, and antiandrogens) biological therapies (interferons, colony-stimulating factors [CSFs], and monoclonal antibodies [MABs]) targeted cancer therapies (STIs) vaccines radioactive isotopes What are antimetabolites? - answer- These are chemotherapy agents which target S phase by stopping DNA replication/repair. Cell-cycle specific. - Used for rapidly proliferating neoplasms - Methotrexate and fluorouracil What is MOA for antimetabolites? - answerinterfere with DNA synthesis, repair, and cellular replication What is methotrexate? - answerUsed also for severe psoriasis, rheumatoid arthritis and lupus What is flurouracil? - answerTopical cream to treat certain cancers, warts Methotrexate and Fluorouracil are both used how to treat cancer? - answerIV Antimetabolites are high cellular turnover are most sensitive in what? - answerNeoplasms Hair follicles Buccal lining GI tract lining