Module 1: Basic Principles of Pharmacology, Section 3: Clinical Pharmacokinetics Exam Questions And Answers 100% Solved

Module 1: Basic Principles of Pharmacology, Section 3: Clinical Pharmacokinetics Exam Questions And Answers 100% Solved What is pharmacokinetics? - answer- study of drug absorption, distribution, metabolism, and excretion as a function of time, precisely and quantitatively What is the goal of clinical pharmacokinetics? - answer- determine dosage regimen that provides optimal drug therapy for an individual - the drug concentration is in the therapeutic range and it produces minimal adverse effects What is apparent volume of distribution? - answer- volume in which a drug appears to be distributed, Vd (units of volume) - apparent because it does not represent an actual volume somewhere in the body, but rather is a calculated value, arrived at using the Vd formula What is the formula for apparent volume of distribution? - answerVd = total amount of drug in the body divided by concentration of drug in the plasma Vd = dose of drug / [drug in plasma] What is the distribution of body water? - answerTotal body water - 42 L Intracellular fluid - 28 L Extracellular fluid - 14 L —> Intravascular fluid - 3 L; interstitial fluid - 11 L What is total body water? - answer- total amount of fluid in body, commonly divided into intracellular and extracellular fluid What is intracellular fluid? - answer- fluid in cells What is extracellular fluid? - answer- fluid outside of cells, divided into intravascular and interstitial fluid What is intravascular fluid? - answer- fluid inside blood and lymphatic vessels What is interstitial fluid? - answer- fluid surrounding cells and tissues