CCTC NATCO- Pharmacology UPDATED Test Questions and CORRECT Answers

CCTC NATCO - Pharmacology UPDATED Test Questions and CORRECT Answers Goals of Immunosuppression include... ✔✔✔ To prevent acute rejection Improve graft survival Improve patient survival to maintain good quality of life Immunosuppression is individualized due to... ✔✔✔ individual drug toxicity to decrease specific side effects changed based on individual immunologic risk tprovide lowest levels of medication and to wean off steroids Too much medication can cause... ✔✔✔ nephrotoxicity infection malignancy neurotoxicity Too little medication can c ause... ✔✔✔ rejection graft loss Induction agents are... ✔✔✔ intense prophylactic therapy given at time of transplant Induction agents are given when... ✔✔✔ rejection risk is highest Typical maintenance therapy includes... ✔✔✔ CNIs: form the cornerstone of immunosuppressive therapy Antimetabolites (AZA, MMF) Corticosteroids Adjuvant agents are... ✔✔✔ medications prescribed in combination with CNI Rescue therapy is... ✔✔✔ intense therapy utilized in response to a rejection episode Interleukin 1 inhibitors in clude... ✔✔✔ Corticosteroids Calcineurin inhibitors include... ✔✔✔ tacrolimus cyclosporine Antiproliferative agents include... ✔✔✔ azathioprine mycophenolate mofetil mTOR inhibitors include... ✔✔✔ sirolimus everolimus Antibodies include... ✔✔✔ Atgam thymoglobulin basilixamab rituximab alemtuzumab IVIG Advantages of induction agents ATG (Polyclonal) include... ✔✔✔ stronger can be used to treat rejection Disadvantages of induction agents ATG (Polyclonal) include... ✔✔✔ common acute side effects