UNE BIOCHEM FINAL Exam 2024 Questions & Answers!

In the liver, which of the following key inhibitory events ensures that newly synthesized palmitoyl-CoA is not immediately oxidized? Carnitine palmitoyl transferase-I (CPTI) by palmitoylcarnitine Carnitine palmitoyl transferase-II (CPTII) by acetyl-CoA Acyl-CoA synthetase by malonyl CoA Carnitine palmitoyl transferase-I (CPTI) by malonyl-CoA Carnitine acylcarnitine translocase (CAT) by palmitoyl-CoA - ANSWERSCarnitine palmitoyl transferase-I (CPTI) by malonyl-CoA Malonyl-CoA produced in the cytosol as part of fatty acid synthesis will inhibit the transport of fatty acids across the mitochondrial membrane such that fatty acid synthesis is not occurring at the same time as β-oxidation Which of the following enzymes used for ketone oxidation is not found in liver cells? Thiolase (acetyl-CoA C-acetyltransferase) HMG-CoA synthase Thiophorase (succinyl-CoA:acetoacetate transferase) β-hydroxybutyrate dehydrogenase - ANSWERSThiophorase (succinyl-CoA:acetoacetate transferase) An individual goes to bed around 8 pm and doesn't wake up until 9 am the next morning. During this time, which of the following is the primary oxidizable substrate for skeletal muscle? Lactate Free fatty acids Glycogen Amino acids - ANSWERSFree fatty acids Under fasted conditions as described above the skeletal muscle and liver would be oxidizing free fatty acids as a means of producing ATP. Ketogenesis is regulated by the rate of several other processes. Which of the following would decrease the rate of ketone body synthesis? Increased lipolysis Increased β-oxidation Increased flux through the TCA cycle. Increased transport of FFA across the mitochondrial membrane - ANSWERSIncreased flux through the TCA cycle.