UNE Biochemistry Final 2024 Questions & Answers 100% Correct!

A comatose infant is brought to the ER. In the course of the examination, plasma ammonia was found to be elevated 20-fold over normal values. Urine orotic acid and uracil were both greater than normal. A defect of which of the following enzymes is the most likely diagnosis? - ANSWERSOrnithine transcarbamoylase Your patient presents with a deficiency of the enzyme that catalyzes synthesis of N-acetylglutamate (NAGs). Which of the following would be a consequence of this deficiency in the patient? - ANSWERSIncreased amino acids in the blood The cellular uptake of LDL increases intracellular cholesterol levels. This has which of the following impacts on de novo cholesterol synthesis? - ANSWERSIncreases degradation of HMG-CoA reductase Dietary cholesterol is primarily transported in the body by which of the following lipoproteins? - ANSWERSChylomicron Secondary bile salts are generated by bacterial modification of primary bile salts in the intestinal lumen. These modifications have which of the following impacts on bile salt solubility? - ANSWERSDecrease solubility A 47-year-old male is prescribed a statin (HMG-CoA reductase inhibitor) to manage his elevated LDL cholesterol. What is the initial mechanism of action for obtaining the desired effect in this man? - ANSWERSDecreasing hepatic cholesterol biosynthesis A deficiency in the LDL receptor will result in an initial decrease in which of the following? - ANSWERSIntracellular cholesterol A 45-year-old man has a mild heart attack and a history of vascular disease. He is placed on a Mediterranean diet and statin drug therapy. Which of the following will be the most likely result of this drug therapy? - ANSWERSLow blood LDLs A 45-year-old man is found to have an elevated serum triglycerides of > 730mg/dL. He tells you he forgot to fast before his visit and he ate a full breakfast of bacon and eggs before the labs were drawn. Which of the following lipoproteins would be the largest contributors to a measurement of plasma triglycerides in this situation? - ANSWERSChylomicrons and VLDLs In the reaction catalyzed by cholesterol ester transfer protein (CETP), the VLDL particle receives which of the following compounds from HDL particles? - ANSWERSCholesterol-ester In r