CRNA Interview Drugs Test Questions and Answers 100% Solved

CRNA Interview Drugs Test Questions and Answers 100% Solved Propofol MOA ️️GABA agonist; Propofol is a short-acting, lipophilic intravenous general anesthetic. The drug is unrelated to any of the currently used barbiturate, opioid, benzodiazepine, arylcyclohexylamine, or imidazole intravenous anesthetic agents. Propofol causes global CNS depression, presumably through agonism of GABAA receptors and perhaps reduced glutamatergic activity through NMDA receptor blockade. Propofol dosing ️️1-2 mg/kg initial dose; 25-150 mcg/kg/min infusion rate Ketamine MOA ️️NMDA(n-methyl d-aspartate) (nerve cell) receptor antagonist; Produces a cataleptic-like state in which the patient is dissociated from the surrounding environment by direct action on the cortex and limbic system. Ketamine is a noncompetitive NMDA receptor antagonist that blocks glutamate. Low (subanesthetic) doses produce analgesia, and modulate central sensitization, hyperalgesia and opioid tolerance. Reduces polysynaptic spinal reflexes. Ketamine dosing ️️1-2 mg/kg; 0.3-1.2 mg/kg/hr continuous rate Fentanyl MOA ️️Provides analgesia and sedation by acting on the opiate receptors in the brain, blocking sensation of pain. Binds with stereospecific receptors at many sites within the CNS, increases pain threshold, alters pain reception, inhibits ascending pain pathways