ONS CHEMO Exam | Questions & 100% Correct Answers (Verified) | Latest Update | Grade A+

Common alkylating agents? Correct Answer: The most common alkylating agents known as nitrogen mustards typically include Cyclophosphamide (Cytoxan®) Ifosfamide (Ifex®) Bendamustine (Treanda®). Common platinum-based drugs include Cisplatin (Platinol®) Carboplatin (Paraplatin®). Nitrosoureas Carmustine (BiCNU®) Lomustine (CeeNu®) Streptozocin (Zanosar®) Things to remember w/ Alkylating agents? 2 Correct Answer: Cyclophosphamide (and Ifosfamide) can cause Hemorrhagic cystitis (hydration and give Mesna). Oxaliplatin can cause severe Peripheral neuropathy (exacerb. by cold - avoid cold air/drinks). Cisplatin can cause severe nephrotoxicity. Carboplatin can cause severe thrombocytopenia. Nitrosoureas: can cause severe pulmonary/nephro toxicity. Common antimetabolites: Correct Answer: Azacitidine (Vidaza®) Capecitabine (Xeloda®) Decitabine (Dacogen®) Cytarabine (Ara-C) Fluorouracil (5-FU) Methotrexate (MTX®) Things to remember w/ Antimetabolites Correct Answer: Uridine Triacetate w/in 96 hrs for 5-FU Calcium Leucovoran to prevent AKI w/ large doses of methotrexate. Oral mucositis (esp. w/ 5-FU) - give popsicle