NRNP 6675 Mood Disorders
What group of drugs are extremley dangerous to use for mood disorders? What does lithium do? Monovalent cation that is well absorbed. Complete in 6-8 hours, peak levels in 30min-2 hours •Distributed in total body water, some sequestration in bone. No protein binding •not metabolized •excreted in urine (90%) •plasma ½ life 20 hours •Resembles Na+ ion -substitute for sodium in action potential -Li+/Na+ exchanger •Effects on neurotransmitters -enhances some actions of serotonin -↓ norepinephrine and dopamine turnover -may block the development of dopamine receptor sensitivity -may augment the synthesis of acetylcholine, perhaps by increasing choline uptake into nerve terminals Lithium MOA?
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nrnp 6675 mood disorders what group of drugs are e
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