Kaplan and Sadock's Chapter 13 & 26
Questions and Correct Answers 2024
13.1. Which of the following statements about the dopamine hypothesis of
schizophrenia is true?
A. Dysregulation of dopaminergic neurotransmission is caused by postsynaptic
sensitivity.
B. Dopamine release caused by amphetamine challenge is higher during remission.
C. Higher amphetamine-provoked dopamine release predicts worsening of psychotic
symptoms.
D. Overactivity of dopamine in the subcortical basal ganglia contributes to negative
symptoms.
E. There is a lower occupancy of D2/3 receptors in relapsed patients. - ANSWERS-C.
Higher amphetamine-provoked dopamine release predicts worsening of psychotic
symptoms.
13.2. True statements about hypothesized neurobiological models of schizophrenia
include
A. Genes function in part by increasing vulnerability to environmental factors.
B. Environmental factors increase risk by producing subtle brain damage.
C. The apparent lack of gliosis in postmortem studies implicates in utero factors.
D. As the prefrontal cortex matures, behavioral and cognitive sequelae of subtle
structural deficits become manifest.
E. All of the above - ANSWERS-E. All of the above
13.3. With regard to the ventricular size in schizophrenia, which of the following
statements is true?
A. Patients with schizophrenia invariably demonstrate significant enlargement of the
fourth ventricle only.
B. Ventricular enlargement is a pathognomonic finding in schizophrenia.
C. Ventricular changes in schizophrenia are likely to be specific for the
pathophysiological processes underlying this disorder.
D. All of the above
E. None of the above - ANSWERS-E. None of the above
13.4. All of the following lead to an increased risk of schizophrenia except
A. having a deviant course of personality maturation and development
B. having previously attempted suicide
C. having a schizophrenic family member
D. having a history of temporal lobe epilepsy
E. having low levels of monoamine oxidase, type B, in blood platelets - ANSWERS-B.
having previously attempted suicide
, 13.5. True statements about violence and schizophrenia include all of the following
except
A. Violence in a hospital setting can result from undiagnosed neuroleptic-induced acute
akathisia.
B. Patients with schizophrenia are more violent as a group than the general population.
C. It is more difficult to prevent most schizophrenic homicides compared with the
general population.
D. Patients with disorganized schizophrenia are at much greater risk to commit violence
than those with paranoid schizophrenia.
E. Command hallucinations do not appear to play a particularly important role in
violence. - ANSWERS-D. Patients with disorganized schizophrenia are at much greater
risk to commit violence than those with paranoid schizophrenia.
13.6. Which of the following statements best describes a characteristic of the
epidemiology of schizophrenia?
A. Female patients with schizophrenia are more likely to commit suicide than are male
patients.
B. In the northern hemisphere, schizophrenia occurs more often among people born
from July to September than in those born in the other months.
C. Reproduction rates among people with schizophrenia are typically higher than those
among the general population.
D. Patients with schizophrenia occupy about 50 percent of all hospital beds.
E. Some regions of the world have an unusually high prevalence of schizophrenia. -
ANSWERS-E. Some regions of the world have an unusually high prevalence of
schizophrenia.
13.7. True statements about eye movement dysfunction in schizophrenia include
A. Abnormal eye movements occur more often in patients with schizophrenia compared
with control subjects.
B. Eye movement dysfunction is associated with a frontal lobe pathology.
C. Eye movement dysfunction is independent of drug treatment.
D. Eye movement dysfunction is seen in first degree probands.
E. All of the above - ANSWERS-E. All of the above
13.8. In general, pooled studies show concordance rates for schizophrenia in
monozygotic twins of
A. 0.1 percent
B. 5 percent
C. 25 percent
D. 40 percent
E. 50 percent - ANSWERS-E. 50 percent
13.9. A schizophrenic patient who states that he feels his brain burning is most likely
experiencing a
A. cenesthetic hallucination
B. delusional feeling
Questions and Correct Answers 2024
13.1. Which of the following statements about the dopamine hypothesis of
schizophrenia is true?
A. Dysregulation of dopaminergic neurotransmission is caused by postsynaptic
sensitivity.
B. Dopamine release caused by amphetamine challenge is higher during remission.
C. Higher amphetamine-provoked dopamine release predicts worsening of psychotic
symptoms.
D. Overactivity of dopamine in the subcortical basal ganglia contributes to negative
symptoms.
E. There is a lower occupancy of D2/3 receptors in relapsed patients. - ANSWERS-C.
Higher amphetamine-provoked dopamine release predicts worsening of psychotic
symptoms.
13.2. True statements about hypothesized neurobiological models of schizophrenia
include
A. Genes function in part by increasing vulnerability to environmental factors.
B. Environmental factors increase risk by producing subtle brain damage.
C. The apparent lack of gliosis in postmortem studies implicates in utero factors.
D. As the prefrontal cortex matures, behavioral and cognitive sequelae of subtle
structural deficits become manifest.
E. All of the above - ANSWERS-E. All of the above
13.3. With regard to the ventricular size in schizophrenia, which of the following
statements is true?
A. Patients with schizophrenia invariably demonstrate significant enlargement of the
fourth ventricle only.
B. Ventricular enlargement is a pathognomonic finding in schizophrenia.
C. Ventricular changes in schizophrenia are likely to be specific for the
pathophysiological processes underlying this disorder.
D. All of the above
E. None of the above - ANSWERS-E. None of the above
13.4. All of the following lead to an increased risk of schizophrenia except
A. having a deviant course of personality maturation and development
B. having previously attempted suicide
C. having a schizophrenic family member
D. having a history of temporal lobe epilepsy
E. having low levels of monoamine oxidase, type B, in blood platelets - ANSWERS-B.
having previously attempted suicide
, 13.5. True statements about violence and schizophrenia include all of the following
except
A. Violence in a hospital setting can result from undiagnosed neuroleptic-induced acute
akathisia.
B. Patients with schizophrenia are more violent as a group than the general population.
C. It is more difficult to prevent most schizophrenic homicides compared with the
general population.
D. Patients with disorganized schizophrenia are at much greater risk to commit violence
than those with paranoid schizophrenia.
E. Command hallucinations do not appear to play a particularly important role in
violence. - ANSWERS-D. Patients with disorganized schizophrenia are at much greater
risk to commit violence than those with paranoid schizophrenia.
13.6. Which of the following statements best describes a characteristic of the
epidemiology of schizophrenia?
A. Female patients with schizophrenia are more likely to commit suicide than are male
patients.
B. In the northern hemisphere, schizophrenia occurs more often among people born
from July to September than in those born in the other months.
C. Reproduction rates among people with schizophrenia are typically higher than those
among the general population.
D. Patients with schizophrenia occupy about 50 percent of all hospital beds.
E. Some regions of the world have an unusually high prevalence of schizophrenia. -
ANSWERS-E. Some regions of the world have an unusually high prevalence of
schizophrenia.
13.7. True statements about eye movement dysfunction in schizophrenia include
A. Abnormal eye movements occur more often in patients with schizophrenia compared
with control subjects.
B. Eye movement dysfunction is associated with a frontal lobe pathology.
C. Eye movement dysfunction is independent of drug treatment.
D. Eye movement dysfunction is seen in first degree probands.
E. All of the above - ANSWERS-E. All of the above
13.8. In general, pooled studies show concordance rates for schizophrenia in
monozygotic twins of
A. 0.1 percent
B. 5 percent
C. 25 percent
D. 40 percent
E. 50 percent - ANSWERS-E. 50 percent
13.9. A schizophrenic patient who states that he feels his brain burning is most likely
experiencing a
A. cenesthetic hallucination
B. delusional feeling
