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Exam (elaborations)

NBEO Pharmacology Mandatory Revision Questions and CORRECT Answers

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Bacitracin MOA and toxicity? - inhibits cell wall synthesis - transfer of peptidoglycan into the growing bacterial cell wall. It is toxic (bacteriCIDAL) so it is only used as an ointment. penicillin and cephalosporin MOA - Irreversibly bind to penicillin-binding proteins in cell wall [like transpeptidases, which cross-link peptidoglycan]. Aminoglycoside and tetracycline MOA - Bind to 30S subunit of ribosome Buy AT 30 CEL 50 Chloramphenicol, macrolides, clindamycin MOA - Bind to 50S ribosomal subunit Buy AT 30 CEL 50

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