Optom 261 - Clinical Ocular Pharmacology TOP Tested Questions and CORRECT Answers

Muro 128 - - Ophthalmic NaCl (sodium chloride) - Hypertonic solution (2 & 5%) and ung (5% only) - Solution stings, ung doesn't - Treats → Fuchs, corneal edema, RCE Viscosity Enhancing Agents - - Increase contact time - hydroxypropyl methylcellulose (HPMC)* - hyaluronic acid (sodium hyaluronate; healing properties; shearing forces)**** - carboxymethylcellulose (CMC; mucoadhesion)** - polyacrylic acids (carpool gels; polopine gel; Vexol; Betoptic-S; Azopt) - cation exchange resins (Amberlite; reduce amount of free drug; particles of drug/resin suspended with vehicle to increase viscosity and contact time; Betoptic-S) - * Can have therapeutic action on their own - Gelrite: Gels in the presence of cations. Prolongs contact time, enhances corneal penetration, prolongs action of drugs. Timoptic XE. - DuraSite: Azithromycin solution. Mucoadhesive gel forming drop. - Ointments: White petrolatum, mineral oil, lanolin