NR 546 Assessment Test Questions with Correct Answers

NR 546 Assessment Test Questions with Correct Answers Prescribing Pearls Rivastigmine (Exelon) - Answer-Prescribing Pearls Rivastigmine (Exelon) is administered orally or topically (transdermal patch). The transdermal patch is used for dementia associated with Parkinson's disease. Medications that induce or inhibit CYP450 metabolism will not modify rivastigmine (Exelon) metabolism galantamine (Razadyne, Razadyne ER) Mechanism of Action - Answer-Mechanism of Action Galantamine (Razadyne, Razadyne ER) acts by elevating acetylcholine (Ach) in the cerebral cortex, modulating the nicotinic Ach receptors to increase Ach release from existing presynaptic nerve terminals. It also increases glutamate and serotonin levels; however, the benefits of this action are unknown Common Side Effects galantamine (Razadyne, Razadyne ER) - Answer-Common Side Effects gastrointestinal symptoms (nausea, vomiting, diarrhea, anorexia, and weight loss) headache dizziness fatigue galantamine (Razadyne, Razadyne ER) Precautions - Answer-Precautions NSAID use GI bleed asthma or COPD concurrent use with medications that slow or decrease heart rate Contraindications galantamine (Razadyne, Razadyne ER) - Answer-Contraindications severe hepatic impairment severe renal impairment Prescribing Pearls galantamine (Razadyne, Razadyne ER) - Answer-Prescribing Pearls There are two major metabolizing enzymes CYP3A4 and CYP2D6 that increase galantamine (Razadyne, Razadyne ER) concentrations or reductions in clearance and anticholinergic side effects when given concurrently with inhibitors of these enzymes