PC707 Module 7 –Exam with 100% Verified and Updated Solutions

PC707 Module 7 –Exam with 100% Verified and Updated Solutions SSRI drug examples - answerparoxetine (Paxil) citalopram (Celexa) fluoxetine (Prozac) sertraline (Zoloft) SSRI MOA - answerSSRIs block the reuptake of serotonin, resulting in an increased concentration of serotonin in the synapse and increased activation of postsynaptic serotonin receptors. SSRI indications - answerDepression Anxiety GAD SAD, PTSD, PD, OCD SSRI Safety and Considerations - answerAbrupt discontinuation may result in withdrawal symptoms. Serotonin syndrome is a rare but serious complication. Increased suicidal ideation the first 2-3 weeks. May cause n/v, insomnia, weight gain, and sexual dysfunction. Risk for serotonin syndrome. Use caution with elderly. Start low and go slow. SSRI BBW - answerSuicide risk, especially early on, may increase. Antidepressant-induced suicide applies mainly to children, adolescents, and adults younger than 25. SSRI pregnancy and lactation - answerZoloft, Paxil, and Fluvox are safe and first-line in breastfeeding. Prozac is not the first line for breastfeeding. Avoid Paxil in pregnancy. Prozac is the most studied for children. SNRI drug examples - answervenlafaxine (Effexor) desvenlafaxine SR (Pristiq) duloxetine (Cymbalta) SNRI for anxiety - answervenlafaxine (Effexor) duloxetine (Cymbalta) SNRI indications - answerDepression Anxiety SNRI MOA - answerBoost serotonin and norepinephrine SNRI safety and considerations - answerVenlafaxine may cause HTN and must be avoided with MAOI. SNRI BBW - answerSuicide risk, especially early on, may increase. Antidepressant-induced suicide applies mainly to children, adolescents, and adults younger than 25. SNRI special consideration - answerVenlafaxine can be used for post-menopausal hot flashes TCA drug examples - answerAmitriptyline Clomipramine Doxepin Imipramine TCA indication - answerDepression TCA MOA - answerBlock reuptake of norepinephrine and serotonin. TCA safety and considerations - answerAnticholinergic side effects. Use with caution in elderly