PROPHECY Pediatric Pharmacology Latest 2024 Update

1. Child doses should never... ANS Exceed the Adult dose regardless of the size of the child 2. Clarks Rule ANS Pediatric Dose = child weight(kg)/adult weight of 70kg x adult dose Pediatric Dose = child weight(pounds)/adult weight of 150lbs x adult dose 3. Young's Rule ANS Pediatric Dose = adult dose x (child's age in years/child's age + 12) 4. Reasoning for using Surface Area to calculate Pediatric Dose ANS Correlates with physiological variables like cardiac output, liver and renal blood flow, GFR, and body water 5. Pediatric Dose by Surface Area ANS SA of child (m2) / 1.7 x adult dose 6. Factors influencing absorption ANS - Gastric Emptying Time - Intestinal Motility - Intestinal blood flow - Gastric acidity 7. Pediatric Absorption ANS Influencing factors are poorly developed/defined in infan- cy. Enteral absorption is not predictable (generally slower than adults). 8. Topical Absorption ANS Much greater in children than adults, especially high in neonates. Only pharmacokinetic parameter that will INCREASE in children. 9. Pediatric Distribution ANS Increased total body water (extracellular water) in infants and children results in lower peak levels of water soluble drugs. Body fat will increase with age. Pediatric Metabolism ANS Neonatal hepatic function is underdeveloped. Results in prolonged half-lifes of drugs being oxidized (lidocaine, during undergoing glu- curonidation-phase II reactions)