UNE Medical Biochemistry Test 6 with Solutions

If unregulated, which of the following pairs of enzymes would represent a futile cycle? - Fructose 1, 6 bisphosphatase and phosphofructokinase-1 Rotenone blocks complex 1 in the ETC. This increases levels of NADH and would likely impair the function of which of the following enzymes? - Pyruvate dehydrogenase complex Newborn screening shows a biotinidase deficiency in a 2-day old infant. This deficienty impairs the infant's ability to reuse and recycle biotin. Due to this enzymatic deficiency, the activity of which of the following enzymes is likely impaired? - pyruvate carboxylase An individual is recently diagnosed with Type 2 diabetes. In this individual, hyperglycemia may in part be due to inactivity of which of the following glucose transporters on skeletal muscle? - Glut 4 (insulin dependent) The skeletal muscle primarily provides substrate for gluconeogenesis through which of the following processes? - protein catabolism Alanine can be shuttled from the skeletal muscle to the liver where it is deaminated to produce pyruvate. When glucagon is high, pyruvate is primarily used as a substrate for which of the following pathways? - gluconeogenesis Aldolase B facilitates a reaction that cleaves fructose 1-phosphate into two 3-carbon molecules that will enter glycolysis as which of the following compounds? - glyceraldehyde-3-phosphate Within the RBC, NADPH is used for which of the following processes? - to re-reduce glutathione Galactose-1-phosphate is initially converted to glucose-1-phosphate and requires which of the following compounds? - UDP-glucose Which of the following are the two primary products of the Pentose Phosphate pathway? - Ribose-5-phosphate and NADPH Which of the following enzymes is involved in the non-oxidative portion of the Pentose Phosphate Pathway? - transaldolase A patient presents with a deficiency of thiamine. If this patient's liver cells are compared to normal liver cells, which of the following products would be decreased in the patient's cells (compared to the normal cells), if the cells are only given glucose as a fuel? - CO2 (lack of thiamine would reduce activity of PDC - as a result, most pyruvate would be diverted to lactate instead