Class notes
PI3-Kinase Pathway
- Course
- Institution
PI3-Kinase, Lipid Binding Domains, Regulation of fork head localisation, Signalling Growth.
[Show more]
Seller
Follow
jemradford011
Content preview
Cells and ImmunityWeek 4
Mike Fry
PI3- Kinases [PKB/Akt] Pathway
- PI3 Kinase = protein kinase B = Akt
- [PI] = phosphatidylinositol [inner leaflet on membrane phospholipid]
- Cell survival signals in from growth factors or cell-cell and cell matrix via intrigrins
- PI3Kinases discovered in 1980’s linked to many pathways, mainly research was done
on 2 inhibitors; fungal metabolite Wortmannin [WORT] and a product LY294002
which both inhibit PI3K.
o Activators; fMLP/Cytokines/Calcium/Insulin/Growth Factors/ Thrombin/
Integrins/ B&T cell activators
o Function; oncogenic transformation/ regulation of cytoskeleton / differential /
survival / secretion / migration / chemotaxis/ oxidation bursts / insulin-
stimulated glucose uptake / protein trafficking.
- PI3-Kinase;
o Inner leaflet of lipid bilayer;
diacylglycerol
o phosphodiester link.
o In cytosol; inositol head group
o PIK3; phosphorylate HO at position 3
o PIK4; position 4 // PIK5; position 5
o Position 2, 6 unavailable to bind.
Class IA PI3K activated by protein tyrosine kinases [P110αβδ +
p85αβγ]
Class IB PI3K activated by GPCR [p110γ + p101]
Class I phosphorylates if 4/5 already done
Class II PI3K [phosphorylates p3 and p4] // Class III PI3K [only
phosphorylates 3 only if others are not phosphorylated]
- Lipid Binding Domains;
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller jemradford011. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $5.47. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
73314 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now