AAMC FL 1 FULL REVIEW 2024 - Bio-Biochem Exam

AAMC FL 1 FULL REVIEW 2024 - Bio-Biochem Exam Based on the data presented in the passage, which statement best describes the HSP110ΔE9 allele? A.Cancer-promoting and dominant to HSP110WT B.Cancer-promoting and recessive to HSP110WT C.Cancer-suppressing and dominant to HSP110WT D.Cancer-suppressing and recessive to HSP110WT -Answer-Cross out A and B. LOOK AT THE FIGURE! Tumor volume is DOWN. Table 2 shows that HSP110ΔE9 allele when mixed with HSP110WT there is more apoptotic cells. So it's dominant. SLOW THE HECK DOWN AND READ Based on the passage, in MSI CRC primary tumor cells, the size of the deletion in the HSP110 T17 microsatellite is inversely correlated with: A.the amount of HSP110ΔE9 protein expressed. B.the number of mature HSP110WT transcripts synthesized. C.the frequency of the omission of HSP110 Exon 9 during splicing. D.the extent of premature translation termination in Exon 10. -Answer-INVERSELY CORRELATED WITH According to Table 1, as the size of the deletion increases, the amount of HSP110ΔE9 and HSP110WT transcripts synthesized increase and decrease, respectively. also: The larger HSP110 T17 deletions cause Exon 9 to be omitted from the final sequence during pre-mRNA processing. This generates a premature stop codon in Exon 10, resulting in the mutant protein HSP110ΔE9. You're going to have MORE PRE-MATURE transcripts, SO LESS mature ones. A man with a CRC mutation that results in the synthesis of HSP110ΔE9 and a woman that does not carry this mutation in any of her tissues have a child. What is the percent chance that the child will inherit the CRC mutation? A.0% B.25% C.50% D.100% passage: People with MSI CRC have HSP110ΔE9 transcripts in cancerous tissue only. -Answer- YOU AINT GONNA PASS DOWN CANCEROUS TISSUE A! Which nucleotide pairing(s) would be recognized by the MMR system during DNA replication? dTMP and dCMP dGMP and dAMP dAMP and dTMP A.I only B.III only C.I and II only D.I, II, and III -Answer-Looking for mismatched bases!