Advanced Pathophysiology Week 3 Quiz

Advanced Pathophysiology Week 3 Quiz Question 1 2 / 2 pts Clinical manifestations of mild to moderate splenomegaly and hepatomegaly, bronze-colored skin, and cardiac dysrhythmias are indicative of which anemia? Sideroblastic Aplastic You Answered Pernicious Iron deficiency Mild to moderate enlargement of the spleen (splenomegaly) and liver (hepatomegaly) occurs. Occasionally, abnormal skin pigmentation (bronze colored) is seen. Heart rhythm disturbances, along with congestive heart failure, are major life-threatening complications related to cardiac iron overload. Question 2 2 / 2 pts What is the pathophysiologic process of aplastic anemia? Autoimmune disease against hematopoiesis by activated immunoglobulins Inherited genetic disorder with recessive X-linked transmission Malignancy of the bone marrow in which unregulated proliferation of erythrocytes crowd out other blood cells Correct! Autoimmune disease against hematopoiesis by activated cytotoxic T cells Most cases of AA result from an autoimmune disease directed against hematopoietic stem cells. Cytotoxic T cells (Tc cells) appear to be the main culprits. Question 3 2 / 2 pts Pernicious anemia generally requires continued therapy lasting 6 to 8 weeks. Correct! the rest of one’s life. until the iron level is normal.