PC707 Module 4 Unit A

PC707 Module 4 Unit A Loop Diuretic (furosemide) MOA - Answer ️️ -inhibits the sodium-potassium-chloride pump in the kidneys; rapid onset/potent Loop Diuretic (furosemide) Indications - Answer ️️ -pulmonary edema, edema and htn Loop Diuretic (furosemide) BBW - Answer ️️ -excess doses can lead to profound diuresis with water and electrylye depletion Thiazide diuretics (MOA) - Answer ️️ -Inhibits sodium reabsorption in nephron increases excretion of Na/Cl/K/Water Hydrochlorothiazide Indications - Answer ️️ -Indicated in essential htn, edema, diabetes insipidus peaks in 4-6 hours Hydrochlorothiazide considerations - Answer ️️ -hypokalemia, hyperglycemia, hyponatremia Potassium-Sparing diuretics (Spironactone) MOA - Answer ️️ -Blocks aldosterone in the distal nephron, Retention of potassium, Increased excretion of sodium Potassium-Sparing diuretics (Spironactone) Indications - Answer ️️ -Hypertension, Edematous states, Heart failure (decreases mortality in severe failure), Primary hyperaldosteronism, Premenstrual syndrome, Polycystic ovary syndrome, Acne in young women. RAAS (Renin-Angiotensin-Aldosterone System) - Answer ️️ -A cascade of events that Helps manage BP, Regulates vascular resistance and tone. Angiotensin 2 is a potent vasoconstrictor! Therefore the goal of treatment is usually directed at Angio2. RAAS (Renin-Angiotensin-Aldosterone System) BBW - Answer ️️ -FETAL INJURY. Contraindicated in PREGNANCY The RAAS system is useful in - Answer ️️ -regulating BP, especially in the presence of hemorrhage, dehydration, or sodium depletion ANGIOTENSIN 2 Acts in two ways - Answer ️️ -Constricts renal blood vessels, Acts on the kidney to promote retention of sodium and water and excretion of potassium with Aldosterone. Angiotensin-Converting Enzyme (ACE) Inhibitors: " PRIL" MOA - Answer ️️ -block the conversion of angiotensin I to angiotensin II by inhibiting the angiotensin-converting enzyme- a potent vasoconstrictor Angiotensin-Converting Enzyme (ACE) Inhibitors: " PRIL" Indications: - Answer ️️ - Hypertension, Heart failure, Myocardial infarction (MI), Diabetic and nondiabetic nephropathy, Prevention of MI, stroke, and death in patients at high cardiovascular risk