Frontier PC 707 Advanced Pharmacology Final Safety Exam Questions & Answers 100% Correct

Understand PLLR: Drugs in Pregnancy and Lactation: Improved Benefit-Risk information. - ANSWER-June 2015; 3 sections pregnancy-L&D, Lactation-nursing mothers; Fe/males of reproductive age; labeling updated as new information arrives, more current information to discuss risk vs benefit Type 1-IgE - ANSWER-Immediate hypersensitivity ex) angioedema, anaphylaxis Type 2-antibody Dependent - ANSWER-minutes to days ex) heparin induced thrombocytopenia Type 3- Immune Complex hypersensitivity - ANSWER-ex) arthrus reaction to tetanus Type 4- non-IgE, Cell mediated delayed - ANSWER-48-72 hours (delayed) ex) drug rash, Eosinophilia, poison Ivy, What are ADRs? What is the APRNs responsibility in ADRs? - ANSWER-Adverse drug reactions 1) pharmacological (predictable) 2) idiosyneratic (unpredicted/severe); APRN: document & record specific reaction & drug; injury involved; FDA reporting Concepts of pharmacokinetics and pharmacodynamics in safety. - ANSWER-Pharmacokinetics- how body handles drug or how it moves through the Understand biotransformation, enzyme induction and inhibition and Grapefruit and CYP 450. - ANSWER-enzyme Inhibitors: decrease CYP450 enzymes, increasing pharmacological action of the drug (more drug, more action); basically inhibit the metabolizing system. Enzyme Induction: induces the CYP450 causing increased amount of CYP450 which results in the increased metabolism, which decreases