Pharmacology Exam 1 with correct answers

pharmacokinetics - relationship between drug dosage and concentration in plasma over time, determines onset, duration, and intensity of drug pharmacodynamics - relationship between drug concentration over time and therapeutic response chemical specificity for receptors - specificity between receptors and bonds, EX strict structural requirements for binding receptor saturability - only a finite number of receptors that can be occupied receptor affinity - measure of attraction between drug and receptor drug potency - dose required to have certain effect, related to affinity of receptor ED50 - dose which produces 50% of maximum effect, used to compare drugs in terms of potency drug efficacy - maximal effect achievable for a drug, related to number of receptor/complexes formed, intrinsic activity of drug in activating receptor full agonist - affinity to, and full activator, of receptor (high intrinsic activity/efficacy), increases activity above basal level of receptor where receptor has a constitutive (intrinsic basal) level of activity in the absence of a ligand inverse agonist - affinity to, and full activator of receptor (high intrinsic activity/efficacy), but has exact opposite effect of full agonist (metoprolol), decreases activity below basal level of receptor where receptor has a constitutive (intrinsic basal) level of activity in the absence of a ligand partial agonist - affinity to receptor but only partially activates a receptor, produces less than the ceiling effect of a full agonist pure antagonist