NR325 Exam 1 2023

NR325 Exam 1 2023 Hypothyroidism is a deficiency of thyroid hormone that causes a general slowing of the metabolic rate. -more common in women Primary hypothyroidism caused by destruction of thyroid tissue or defective hormone synthesis Brainpower Read More Previous Play Next Rewind 10 seconds Move forward 10 seconds Unmute 0:14 / 0:15 Full screen Secondary hypothyroidism is caused by pituitary disease with decreased TSH secretion or hypothalamic dysfunction with decreased thyrotropin-releasing hormone (TRH) secretion. most common cause of hypothyroidism iodine deficiency Hashimoto's thyroiditis Graves' disease thyroidectomy RAI therapy Drugs(amiodarone/lithium) Manifestations of hypothyroidism Everything slows!! tired lethargic personality changes impaired memory slowed speech decreased initiative weight gain depression SOB on exertion low exercise tolerance anemia myxedema cold and dry skin hoarseness hair loss constipation cold intolerance Complications of hypothyroidism myxedema coma myxedema coma medical emergency -precipitated by infection, drugs , exposure to cold, and trauma. -subnormal temperature, hypotension, and hypoventilation. TX: IV thyroid hormone replacement Labs for hypothyroidism TSH: high T4: low -thyroid antibodies Treatment for hypothryoidism Levothyroxine: start at a low dose, lifelong therapy -low-calorie diet Hyperthyroidism hyperactivity of the thyroid gland with sustained increase in synthesis and release of thyroid hormones. -more common in women Causes of hyperthyroidism Graves' disease toxic nodular goiter thyroiditis excess iodine intake pituitary tumors thyroid cancer thyrotoxicosis physiologic effects or clinical syndrome of hypermetabolism resulting from excess circulating levels of T4, T3, or both. Graves' disease an autoimmune disease of unknown cause characterized by diffuse thyroid enlargement and excess thyroid hormone secretion -antibodies against TSH Manifestations of hyperthyroidism Everything is HYPER! goiter exophthalmos increased appetitie thirst weight loss spleenomegaly/heptomegaly insomnia rapid speech smooth/moist skin thin/brittle nails clubbing diaphoresis heat intolerance Labs for hyperthyroidism Increased T3 & T4 Decreased TSH Complications of hyperthyroidis