PC707 Mod 1 Exam Questions With Verified Answers

Phase 1 - Answer Evaluate safety, 40-50 healthy volunteers Phase 2 - Answer Evaluate efficacy, 10-100 patients Phase 3 - Answer Statistical analysis of safety & efficacy, double blinded RCT Phase 4 - Answer post marketing surveillance Absorption - Answer The movement of a drug from the site of administration into circulation Bioavailability - Answer Amount of ACTIVE drug that reaches systemic circulation Distribution - Answer The movement of a drug form systemic circulation to the site of action Protein binding - Answer Drugs are inactive when bound, free circulating drug is available for use Agonist - Answer Drug that activates it's receptor Antagonist - Answer Deactivates receptor/ prevents receptor activation Metabolism - Answer Enzymatic alteration of a drug Induction - Answer Drugs which increase rate of metabolism Decreases AUC Drug may not reach therapeutic level Inhibitors - Answer Drugs that decrease the rate of metabolism Increased AUC Drug may become toxic/ more severe adverse effects Prodrug - Answer Drug which is inactive until it is metabolized Able to cross BBB prior to activation