BMTCN Chapter 4 questions well answered rated A+

BMTCN Chapter 4BCNU - correct answer Carmustine Causes DNA Cross links and strand breaks Inhibits DNA repair Crosses blood/brain barrier Need pre/post hydration BCNU Side Effects - correct answer N/V Infusion reactions nephrotoxicity (increased Crea & BUN) pulmonary - cough, dyspnea, tachypnea acute lung injury - 10-30 days post infusion (tx w/ steroids; can be fatal) Busulfan - correct answer *Alkylating agent*-->cross-links DNA-->damages DNA Crosses blood brain barrier (can cause seizures) Dose based on PKs busulfan side effects - correct answer neurotoxicity n/v, diarrhea, stomatitis, anorexia, hepatitis, SOS hyperpimentation, rash, hair loss (can be permanent) pulmonary fibrosis, sterility, menopause Carboplatin - correct answer alkylating agent binds to DNA interfering w/ production in interstrand DNA cross links Excreted in Urine - HYDRATION carboplatin side effects - correct answer N/V electrolyte imbalance renal insufficiency acidosis hypernatremia Long Term: nonreversible ototoxicity neurotoxicity Cyclophosphamide - correct answer alkylating agent forms carbonium ions through release of sulfonate group (alkylation of DNA) Not cell cycle phase specific Inactive until converted in liver and excreted by kidneys Cyclophosphamide side effects - correct answer monitor I/Os, lytes, UA for hematuria Histamine rxn: burning in nose, jaw, facial pain Cardiomyopathy, hemorrhagic myocardial necrosis, CA vasculitis _ Get BL echo and ekg Hemorrhagic cystitis SIADH, N/V Diarrhea Alopecia, hyperpigmentation, ridging of nails Pneumonitis (rare), fibrosis Cytarabine - correct answer antimetabolite - inhibits DNA synthesis in the s-phase metabolized by the liver and excreted in the urine