BMTCN Study questions well answered 2023/2024

BMTCN StudyMyeloid - correct answer erythrocyte, platelets, neutrophil, basophil, eosinophil, monoblastic, macrophage, monocyte lymphoid - correct answer pre- B cell, pre-t cell, plasma cell, natural killer cell, t lymphocyte innate immunity - correct answer occurs naturally- phagocytes release inflammatory mediators acquired immunity - correct answer response of either b or t cells to antigens senescence - correct answer loss of cells power to divide and grow immunosenescence - correct answer reduction in size of thymus and function of immune cells first responders - correct answer myeloid second responders - correct answer lymphoid- pathogen specific syngeneic - correct answer identical twin, don't need immunosuppression, con- no graft vs tumor effect graft vs. tumor effect - correct answer -promoted by withdrawal of immunosuppressant therapy -promoted by DLIs -dec. in absence of acute gvhd -higher rate of relapse DLI - correct answer infusion of lymphocytes from donor given when there is relapsed disease. Attempt to create GVT effect PBSCT - correct answer - 70 %, - faster engraftment, no anesthesia risks, dec. likelihood of contamination by tumor, -higher risk of gvhd, - but better gvt effect- so dosent make sense for SCD G-CSF - correct answer filgrastim. a glycoprotein stimulates the production of stem cells by binding to certain cell surface areas GM-CSF - correct answer sargramostim. lower stem cell yields. and inc adverse events. similar mechanism of action chemo induced mobilization - correct answer chemo causes reduction in production of blood cells thus stimulating hematapoetic recovery. -cyclophosphamide -paclitaxel -etoposide -cytarabine -improved mobilization -more rapid engraftment -reduced risk of tumor cell contamination chemokine antagonist mobilization - correct answer directly induce mobilization by working as antagonist between the chemokine stromal-derived-factor- 1 and receptor CXCR4. -Plerixafor -often in combination with GCSF red bone marrow - correct answer produces stem cells that create rbcs, whit bcs, and plts. found in long and flat bones yellow bone marrow - correct answer produce stromal stem cells that produce fat, cartilage and bone. found in long bones