BMTCN ch.03 questions with 100% complete solutions 2023/2024 passed

BMTCN ch.03pre-transplant workup/evaluation - correct answer -labs: CBC+diff, chems, hep B&C, HIV, human t cell leukemia virus type 1, CMV, HSV, VZV, pregnancy, ABO/RH-, HLA, serology, rapid plasma regain testing -organ function tests: EF>50%, echo, EKG -disease eval: BMBx, LP, CT, MRI, bone scans/survey, tumor markers, PET, 24-hr urine, Ig tests, urine catecholamines -psych, financial, psychosocial eval, comorbidities, performance status, dental exam, caregiver availability -avoid bias by having another provider to donor's health assessment other than recipients HLA - correct answer human leukocyte antigens -glycoproteins residing on surface of cells located on chromosome 6 -play role in immune system ability to recognize self -unique to each person -produce immune cells that destroy antigens -in setting of allo-HSCT, is associated with better outcomes and less r/f GVHD -more common to share in same racial group preferred donor - correct answer male, young, heavier weight no previous pregnancies clean blood samples/no viruses/diseases be aware of special needs of peds/sibling donors prepared with education and know risks and such apheresis - correct answer a technique to collect cells from peripheral blood used after stem cell mobilization -involves using cell separator device to collect stem cells and return plasma and cells back to donors’ bloodstream SE -hypocalcemia: d/t anticough of Nitrate used, fatigue, chills, tingling, dizzy -hypovolemia, thrombocytopenia, chills, HAs usually need a CVC, or need to be super careful/gentle w/PIVs CD34+ cells - correct answer a protein expressed on the surface of hematopoietic stem cells found in bone marrow and UCB higher stem cell doses w/increased pt survival rates and rapid engraftment mobilization - correct answer process by which hematopoietic stem cells are released from bone marrow into peripherally circulating blood main classes of drugs used: hematopoietic growth factorws, chemo, and chemokine antagonists G-CSF (filgrastim) - correct answer glycoprotein that stims production of hematopoietic cells by binding to certain cell surface receptors and is most commonly used for stem cell mobilization SE: bone pain, HA, fatigue, muscle aches, N/V, stomach pain common chemo used for mobilization - correct answer -ex: cyclophosphamide, paclitaxel, etoposide, cytarabine -advantages: improved mobilization, more rapid engraftment, limits tumor cell contamination -disadv: hospitalized to get chemo, SE of chemo, causes extreme decrease in T cells chemokine antagonists - correct answer -work as antagonist b/t chemokine and stromal derived factor 1 and its receptor CXCR4 -ex: plerixafor cyclophosphamide - correct answer -chemotherapy used for mobilization -SE: N/V, myelosuppression, fatigue, reproductive issues, alopecia, hemorrhagic cystitis plerixafor - correct answer (chemokine antag used for mobilization; increases amount of CD34+ cells; SE: leukocytosis, thrombocytopenia, nausea, erythema at injection site, dizzy, diarrhea, fatigue)