BMTCN ch.04 questions with complete solutions 2023/2024

BMTCN ch.04preparative regimens - correct answer aka conditioning regiment part of HSCT when tx malignant diseases goal: eradicate residual disease and/or provide immunosuppression to prevent graft rejection prepare receipients bone marrow to accept new donor cells examples of chemo - correct answer cyclophosphamide busulfan etoposide cytarabine carmustine melphalan myeloablative regimens - correct answer lethal doses of chemo (usually includes alkylating agents) with or without TBI nonmyeloblative - correct answer myelosuppression is reversible and includes within 28 days without stem cell infusion RIC - correct answer reduced intensity conditioning regimens cause cytopenias goal is to induce immunosuppression so the donor immune system can engraft 'less severe' than nonmyeloablative AHSCT conditioning chemo - correct answer myeloablative regimens --> use high-intensity chemo to treat underlying disease melphalan - correct answer -myeloablative -AHSCT -primary choice for MM and amyloidosis BEAM - correct answer carmustine (BCNU), etoposide, cytarabine (ARA-C), and melphalan -myeloablative -AHSCT allo-HSCT chemo - correct answer myeloablative -cyclophos and ATG -TBI w/etop, cyclophos, or busulfan and fludarabine nonmyeloablative as well page 41--chemo regimens see google docs table - correct answer severe aplastic anemia (SAA) - correct answer = autoimmune rxn l/t empty bone marrow and pt unable to produce normal immune cells -biggest challenge is rejection of donor cells (add ATG to help) fanconi anemia (FA) - correct answer = genetic disorder, progressive BM failure, increased r/f cancer -molecular defects that inhibit DNA repair -use ATG