CBE 564 Final Quizlet 2023/2024 verified to pass

CBE 564 Final Quizlet [3/23] BBB - correct answer -- Astrocytes - correct answer -star-shaped -biochemical support -nutrients, ion balance -repair after injury Pericytes - correct answer -wrap around capillaries -blood flow -maintain BBB -immune cell entry Microglia cells - correct answer -immune cells in the brain -scavenge for plaques; damaged or unused neurons or synapses, or infectious agents -survey environment, send and receive signals -Phenotype change, become more reactive, phagocytic Brain endothelium vs systemic vascular endothelium - correct answer -tight junctions -lack fenestrae -limited vesicle formation What are the 4 endogenous mechanisms for traversing the BBB? - correct answer 1. paracellular diffusion 2. transcellular free diffusion 3. carrier-mediated transport 4. BBB disruption What are some carriers that carry molecules across the BBB? - correct answer Glut1- glucose LAT1- neutral amino acids L-Dopa for PD ENT1- nucleoside, adenosine Mct- lactate When establishing QSAR (quantitative structure activity relationships) for free diffusion of lipid soluble drugs, we predict passive diffusion by Lipinski's "Rule of 5": - correct answer 1. Molecular weight/molecular volume 2. Lipophilicity 3. Polar surface area limited 4. Hydrogen bonding potential 5. Molecular charge What are some things you need to do when delivering hydrophilic drugs? - correct answer Mask hydrophilic moieties to render compounds more lipophilic or substrates for transporters ie. L-DOPA to Dopamine for Parkinson's disease How can the BBB be dysregulated in neurological disease? - correct answer 1. loss of tight junction 2. increased enzymatic activity 3. changes in efflux pumps Name some administration techniques with the following attributes: A) must cross BBB B) invasive but no BBB C) less invasive, no BBB D) minimally invasive, no BBB - correct answer A) IM, IV, SC B) Intraparenchymal, intracerebroventricular