NBME CBSE EXAM ACTUAL TEST QUESTIONS WITH VERIFIED ANSWERS

NBME CBSE EXAM ACTUAL TEST QUESTIONS WITH VERIFIED ANSWERS Chagas Disease ---------- Correct Answer--------- Caused by Trypanosoma cruzi parasite passed in the feces of Reduviidae/kissing bug Penetrates broken skin or intact mucous membranes forming a pseudocyst releasing inflammatory infiltrates into myocytes; stains with Giemsa & Wright Romana sign occurs when portal of entry is the conjunctiva or eyelid May resulting in: Enlarged heart- CHF, sudden cardiac arrest Enlarged esophagus- difficulty swallowing Enlarged colon- abdominal pain or constipation Treat with benznidazole or nifurtimox Monocytes ---------- Correct Answer ---------cell with half-moon shaped nucleus that participates in phagocytosis Chronic graft rejection ---------- Correct Answer ---------multifactorial but typically involves arteriosclerosis HLA-B27 ---------- Correct Answer -------- PAIR: Psoriasis Ankylosing spondylitis- chronic synovitis destroying cartilage typically in young men Inflammatory bowel dz- Crohn's & UC Reactive ArthritisReactive Arthritis ---------- Correct Answer---------Arthritis as a reaction to a bacterial infection such as Campylobacter, Chlamydia, Salmonella, Shigella, or Ureaplasma. Associated with conjunctivitis & uveitis Gaucher (Type 1) ---------- Correct Answer ---------AR Lysosomal storage disease Accumulation of sphingolipid glucocerebroside Most common Wrinkled tissue paper I Cell disease ---------- Correct Answer--------- Failure of Golgi apparatus to phosphorylate mannose 6-phosphate the marker to export enzymes to lysosomes resulting in accumulation of lysosomal enzymes in serum Nitroblue tetrazolium test ---------- Correct Answer ---------Aqualitative test to determine defects in NADPH oxidase Negative: CGD Positive: Acute Hepatitis, Mono CGD (chronic granulomatous disease) ---------- Correct Answer ---------inability to produce NADPH oxidase; susceptible to Cat + organisms; elevated neutrophils w/ normal T cell Gp91 phox subunit: heme binding subunit of superoxide generating NADPH Treat with interferon gamma Clarithromycin (macrolide) ---------- Correct Answer -------- ADR of metallic taste & GI Codeine ---------- Correct Answer -------- ADR resp. depression, euphoria, & constipation Cyclobenzaprine ---------- Correct Answer ---------Structurally similar to TCAs w/ anticholinergic side effects used for relief of muscle spasms May exacerbate glaucoma Naproxen ---------- Correct Answer--------- ADR of GI & renal (in elderly) Timolol ---------- Correct Answer---------Used in HTN & glaucoma; ADR of bradycardia & worsening asthma Bacterial vaginosis ---------- Correct Answer--------- Sloughed mucosal cells = clue cells Trichomoniasis ---------- Correct Answer -------- Cilated, motile trophozoites w/ corkscrew-like motility Autism ---------- Correct Answer -------- Lack of eye contact, verbal communication, & separation anxiety; repetitious behavior Emphysema ---------- Correct Answer---------Decreased FEV1/FVC ratio, normal FVC; TLC, FRC, & RV increase