Cells of the immune system
Hematopoiesis
The dynamic process through which the body creates various types of blood cells.
Stem cells in the bone marrow have the capacity to differentiate to all blood cell
types depending on the microenvironment.
It’s vital role in maintain overall health and the immune system’s functionality.
Microenvironment – growth factor
Erythropoietin (EPO), a hormone produced by the kidneys, stimulates the production
of red blood cells in response to low oxygen levels.
Granulocyte – monocyte colony – stimulating factor (GM-CSF) in regulating the
production of Myeloid cell types.
Interleukin – 7 (IL-7) in supporting lymphocyte development.
Cells of the Innate immunity
Most of them are derived from the myeloid lineage.
These include:
- Macrophages
- Monocytes
, - Granulocytes
- Dendritic cells
Granulocytes
- Polymorphonuclear leukocytes PMN (Multilobed nucleus) – neutrophiles,
eosinophils and basophils
- Mast cells
Agranulocytes
- Monocytes and macrophages
Macrophages
Found in various tissues throughout the body
Versatile immune cells
Involved in:
- Phagocytosis
- Antigen presentation to activate the adaptive immune system
- Tissue repair
May be localized and name based on the locations
- Kupffer cells in the liver
- Alveolar macrophages in the lungs
- Microglia in the central nervous systems
- Langhans giant cells in tuberculosis
Hematopoiesis
The dynamic process through which the body creates various types of blood cells.
Stem cells in the bone marrow have the capacity to differentiate to all blood cell
types depending on the microenvironment.
It’s vital role in maintain overall health and the immune system’s functionality.
Microenvironment – growth factor
Erythropoietin (EPO), a hormone produced by the kidneys, stimulates the production
of red blood cells in response to low oxygen levels.
Granulocyte – monocyte colony – stimulating factor (GM-CSF) in regulating the
production of Myeloid cell types.
Interleukin – 7 (IL-7) in supporting lymphocyte development.
Cells of the Innate immunity
Most of them are derived from the myeloid lineage.
These include:
- Macrophages
- Monocytes
, - Granulocytes
- Dendritic cells
Granulocytes
- Polymorphonuclear leukocytes PMN (Multilobed nucleus) – neutrophiles,
eosinophils and basophils
- Mast cells
Agranulocytes
- Monocytes and macrophages
Macrophages
Found in various tissues throughout the body
Versatile immune cells
Involved in:
- Phagocytosis
- Antigen presentation to activate the adaptive immune system
- Tissue repair
May be localized and name based on the locations
- Kupffer cells in the liver
- Alveolar macrophages in the lungs
- Microglia in the central nervous systems
- Langhans giant cells in tuberculosis
