SBB Questions And Answers Verified Review Test A+

SBB Questions And Answers Verified Review Test A+ The Donath-Landsteiner test attempts to detect clinically significant antibodies related to a rare disorder called paroxysmal cold hemoglobinuria. The specificity of this biphasic antibody is directed towards: A. K1 B. P,P1,Pk Glycolipid(Globosides) C.P,P1,Pk Glycophorin D. P,P1,Pk Glycoprotein E. Parvo B19 F. p` antigen - answer-B.P,P1,Pk Glycolipid(Globosides) C.P,P1,Pk Glycophorin The Donath-Landsteiner antibody is characterized by the following clinically significant attributes: A. Transient IgG biphasic hemagglutinin causing extravascular hemolysis B. Transient IgM biphasic hemagglutinin causing extravascular hemolysis C. Transient IgG biphasic hemolysin causing extravascular hemolysis D. Transient IgG biphasic hemolysin causing intravascular hemolysis E. Transient IgG biphasic hemolysin incapable of fixing complement past C4 F. Transient IgM biphasic hemolysin capable of fixing complement past C4 - answer-D. Transient IgG biphasic hemolysin causing intravascular hemolysis In addition to total plasma exchange by apheresis; the recommended, practical, and effective treatment for Donath-Landsteiner Hemolytic anemia (PCH) also includes: A. Supportive Care, and Red Cell transfusion with P antigen negative units through a blood warmer B. Splenectomy C. Corticosteriods D. Supportive Care, and Red Cell transfusion with P antigen positive units through a blood warmer - answer-D. Supportive Care, and Red Cell transfusion with P antigen positive units through a blood warmer. While P negative would be a little more effective they are hard to find. P.S. a splenectomy would only work if this was an extra vascular hemolysis but PCH is intravascular. Given the case presented for PCH, the most likely explanation for the negative DAT testing seen at both of the hospital based blood banks, prior to a positive DAT at the reference lab is: A. Pre-analytical error B. Analytical error C. Analytical limitation D. Pre-analytical limitation E. Failure of Quality Control - answer-C. Analytical limitation The hospital blood bank likely only ran an IgG DAT. So they may miss the C3 reactivity that was detected at the reference lab. Pre-analytical - problem occurs outside the lab. Analytical - problem occurs inside the lab. It is not an error because the test they ran reacted as it was supposed to perform, it was just that there was a limitation to the scope of testing. Most cases of PCH have a history of cold exposure • True or False? - CONTINUES...