Week 8 Pharm 180 (Test questions with errorless answers)

Epoetin alfa MOA correct answers increase production of RBC Epoetin alfa therapeutic use correct answers tx anemia r/t chronic kidney disease, chemotherapy, HIV (zidovudine), increases erythrocyte counts in those undergoing surgery How is epoetin alfa administered? correct answers IV or SUBQ vial should not be agitated, only use for one dose, do not put the needle back into the vial after first puncture, dont mix w/ other meds with this drug and give 1-3x per week what are some complications seen in patients taking epoetin alfa? correct answers Hypertension (due to elevated hematocrit levels), thrombotic events (MI, CVA), DVT, headache, body aches (due to HTN) what are some precautions we should consider for epoetin alfa? correct answers uncontrolled hypertension what is the nursing considerations for epoetin alfa? correct answers monitor blood pressure closely, smaller dosages may be needed for hypertension, dosage is weight based, monitor iron levels and monitor hemoglobin (10-11g/dL), maximum hematocrit (33%) Filgastrim (Neupogen) MOA correct answers increase production of neutrophils (wbc) what is the therapeutic use of filgastrim? correct answers to decrease infx for those with neutropenia, preparation for HSCT Filgastrim administration? correct answers IV, SQ do not combine w/ other meds, use vial once what are some complications seen when taking filgastrim? correct answers bone pain, leukocytosis, splenomegaly (LUQ)/ rupture precautions/contraindications to take when taking filgastrim? correct answers cancer of bone marrow, sickle cell, respiratory disease, pregnancy category C, children what are the nursing considerations for patients who are taking filgastrim? correct answers monitor cbc twice weekly, teach sq administ., tx pain w/ acetaminophen, monitor for LUQ pain oprevelkin (Neumega) MOA: correct answers increases platelet production what is the therapeutic use for oprevelkin? correct answers decreases thrombocytopenia and need for platelet transfusions in pt's undergoing chemotherapy what are some complications seen when taking oprevelkin? correct answers fluid retention (edema, dyspnea), dysrhythmias, vision problems (infx, blurring, edema), anaphylaxis