GLP-1 Agonists Exam Review 2023

GLP-1 Agonists Exam Review 2023 What is a GLP-1 agonist? - ANS-A longer acting analog of GLP-1 (longer than the endogenous GLP-1); activates the GLP-1 receptor How can GLP-1 affect the body? - ANS-Increases amount of insulin produced BEFORE BG elevates (increase beta cell function), lowers glucagon secretion after meals (decrease glucose production), increases CNS satiety (decrease food intake), slows gastric emptying (decrease glucose absorption), and increases glucose uptake into skeletal and adipose tissue When is GLP-1 secreted? - ANS-Upon ingestion of food What does GLP-1 stand for? - ANS-Glucagon-like peptide-1 How is GLP-1 produced? - ANS-By L-cells of the ileum in minutes after oral intake of glucose (does not come from pancreas) Are GLP-1 levels diminished in DM1 or DM2? - ANS-DM2 What enzyme can breakdown GLP-1? - ANS-DPP-IV Brand: Byetta - ANS-exenatide Brand: Bydureon - ANS-exenatide ER Brand: Victoza - ANS-liraglutide Brand: Tanzeum - ANS-albiglutide Brand: Trulicity - ANS-dulaglutide Brand: Adlyxin - ANS-lixisenatide Which is the only GLP-1 agonist that is not a once weekly injection? - ANS-Byetta (exenatide) Which GLP-1 agonists need reconstitution? - ANS-Tanzeum and Bydureon ADRs - ANS-Hypoglycemia (low risk unless paired with secretagogue or insulin), N/V (mostly with exenatide daily; titrate slowly), pancreatitis (rare), weight loss, Where can it be injected? - ANS-Abdomen, thigh, upper arm Which is more effective: once weekly or once daily product? - Continues...