RBC 3 Path Exam 1 Questions With Correct Answers

What are differential diagnosis of trauma to RBCs and what might this lead to? - Answer What is shown in the following? - Answer Microangiopathic Hemolytic Anemia What are shown in the following? - Answer schistocytes (shredded RBCs) What type of anemia is seen in paroxysmal noctural hemogloniuria? - Answer What are presentations and complications of paroxysmal noctural hemoglobinuria? - Answer What are sequella of PNH? - Answer What are diseases associated with hemolysis? - Answer What are causes of bleeding abnormalities? - Answer Describe clinical presentation and severities of abnormalities in clotting factors - Answer Label the intrinsic and extrinsic clotting pathways - Answer How does vitamin K influence clotting? - Answer 1.Vitamin K: Needed for production of factors II, VII, IX, X, protein S a.Often nutritional (diet, modified GI tract) b.Iatrogenic (warfarin) What are screening tests for vitamin K deficiency? - Answer a.Platelet Count (from CBC) b.Prothrombin Time (PT) c.Activated Partial Thromboplastin Time (aPTT) d.Bleeding Time (not reliable) What is von willebrand factor and where is it produced? - Answer Label the following - Answer express von willebrand factor when there is damage to the endothelium causes platelets to clot through GP1B What is von willebrand's disease and how will it present? - Answer List and describe the different types of von willebrand disease - Answer Describe deficiecny, inheritance, and clinical appearance of hemophilia A - Answer Describe clinical presentatin of hemophilia A - Answer Prolonged aPTT (corrects with mixing study) Normal PT Describe deficiency, inheritence, and clinical appearance of hemophilia B - Answer Be familiar with inheritence of hemophilia - Answer Female carrier giving to sons