Immunology Med 3 AUA 2023 Questions With Complete Solutions

Function of Lymph Node correct answer: Nonspecific Filtration by Macrophages, Storage and Activation of B and T Cells for Antibody production In the lymphnode, where are Primary and Secondary Follicles found correct answer: In the Cortex In the Lymph node, what cells are found in the Follicles and where are the Follicles found correct answer: MAINLY B CELLS, Macrophages, and dendritic Cells and found in the Cortex of the lymphnode In the lymph node the medulla is made up of what correct answer: Medullary Cords and Medullary Sinuses In the lymph node, what makes up the Medullary Cords correct answer: Closely packed lymphocytes and plasma cells and medullary sinuses In the lymph node what is the function of the medullary sinuses and what cells does it contain correct answer: It communicates with efferent lymphatics, and contains reticular cells and macrophages What are reticular cells correct answer: A type of fibroblast that synthesizes type III collagen which defect is associated with Ehlers Danlos Syndrome In the lymph node what cells are found in the paracortex correct answer: Houses T cells Where are High Endothelial Venules located and what is their role correct answer: T and B cells enter lymph node through HEV from the blood What part of the lymph node enlarges in extreme cellular immune respone (i.e.) Viral correct answer: The Paracortex Which part of the lymphnode is not well develop in patients with DiGeorge Syndrome correct answer: The paracortex What is DiGeorge Syndrome correct answer: 22q11.2 deletion syndrome, absent of hypoplastic thymus. problems with the immune system's T-cell mediated response In the spleen where are T cells found correct answer: In the Periarterial lymphatic Sheath within the white pulp of the spleen In the spleen where are B cells found correct answer: In Follicles within the white pulp What is the role of macrophages in the spleen correct answer: to remove encapsulated bacteria What cacade of events happen when the spleen is dysfunctional correct answer: First there is a decrease in IgM -> decrease in Complement activation -> decrease in C3b opsonization = increase susceptibility to encapsulated organisms Which encapsulated organisms would you be more susceptible with splenic dysfunction correct answer: Think SSSHaNK