Introduction to clinical chemistry Questions With Complete Solutions.

define clinical chemistry correct answer: the analysis of body substances & interpretation of resultant data as an *AID* to diagnosis, prognosis, and treatment *implies a pathologic change can be distinguished from a non-pathologic change* *requires a point of reference for making a comparison* define reference interval correct answer: an interval of values within the majority of healthy patients values lie this interval of values if used for making comparisons *not the "normal" interval* what is included in the design of a reference interval? correct answer: -A set of selection criteria for reference individuals is chosen & ONLY these individuals are used -95% of values obtained are from the selection criteria-based population -Mean+/-2 SD of a bell curve -mathematical manipulations made to establish the 95% interval for non-gaussian distributions what percent of healthy animals will have values outside of the reference range? correct answer: 5% what animal factors influence selection criteria for a reference interval? correct answer: 1. healthy (#1) 2. demographic: species, breed, age, sex 3. environment/physiologic: diet, fasted or not, reproductive/lactation, excitement, body condition, altitude, medications, season of year what pre-analytical factors influence selection criteria for a reference interval? correct answer: 1. specimen collect