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Lecture notes - Cell And Molecular Biology (Respiration pt 1) - Using Becker's World of the Cell, Global Edition

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If you're studying a life science (e.g. - biomed, bioscience, physiology, sports science, sports physiology etc), then this detailed set of lecture notes on respiration and ATP will help you smash your first set of exams on cell/molecular biology! You'll need an in depth knowledge of respiration and associcated pathways (notably the citric acid cycle) throughout your degree, so this set of notes will be invaluable to you not just in first year, but also in your second and final year as well!

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Metabolism and Metabolic Pathways
Metabolism = 2 definitions:

1) The sum total of the chemical processes that occur in living organisms, resulting in growth,
production of energy, elimination of waste material, etc.

2) The sum total of the chemical processes affecting a particular substance in the body: e.g.
carbohydrate metabolism; iodine metabolism, etc.

Bioenergetics = Study of flow of energy in living systems:

- Autotrophs (e.g. plants) use solar energy and CO2 to make energy-rich molecules (e.g. –
carbs)
- Heterotrophs (e.g. humans) obtain energy in chemical form by degrading molecules made
form autotrophs

Energy = ability to move/change matter

- Kinetic energy = energy of motion
- Potential energy = stored energy
- Chemical energy = stored energy available for release

Autotrophs/Heterotrophs ≠ heat for energy

Autotrophs/Heterotrophs only use Gibb’s free energy (amount of energy capable for doing work e.g.
– ‘free’ solar energy and ‘free’ chemical energy

(Remember, endergonic reaction needs free energy (non-spontaneous) exergonic reaction releases
energy and includes many catabolic reactions)

The chemical energy stored in bonds = due to arrangement of E- in the bonds between their atoms

Metabolic pathways are very complex and break down into 2 main aims:



- Convert nutrient molecules into precursors for cell’s own molecules, build up
larger/macromolecules using the precursors

- Degrade organic molecules into smaller end products (e.g. – lactic acid, CO2)

Anabolic and Catabolic reactions = metabolic terms

Manufacture of proteins from aa = anabolic

Breakdown of glucose during cellular respiration = catabolic

Energy released from catabolic reactions can be used to drive anabolic reactions
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