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Sorbitol has many uses in drug delivery. Which of the following are practical uses of sorbitol? (Select ALL that apply.) A. Sweetener (sugar substitute) B. Humectant C. Plasticizer for gelatin capsules D. Treatment of GI distress in patients with IBS E. Suspending agent - Answer A, B, C Which of the following correctly describes the use of Tween? (Select ALL that apply.) A. It is used most commonly as a thickening agent. B. Tween is a surfactant. C. Surfactants are compounds with polar sides and nonpolar sides. D. The generic name for Tween is polysorbate. E. Surfactants are used most often in ointments. - Answer B, C, D A pharmacist will be compounding an electrolyte rehydration solution by mixing dextrose powder, sodium chloride powder, and potassium citrate powder. The powders are already uniform in particle size and only need to be blended together. Which of the following mortar and pestles should be used? A. Bamboo B. Wedgwood C. Porcelain D. Glass E. Stainless steel - Answer C Rank the following steps used to compound molded tablets. A. Mix the ingredients using geometric dilution. B. Compress the moist powder mixture into a tablet mold and allow to dry to form individual tablets. C. Measure and weigh all ingredients. D. Add alcohol and/or water to moisten the powder mixture. E. Triturate the dry ingredients. - Answer C, E, A, D, B Wetting agents reduce the surface tension between: A. Air and water B. A base and an acid C. Two different powders D. Oil and water E. A solid and a liquid - Answer E Kimberly is compounding a progesterone oral suspension. After weighing and measuring out the ingredients, she will be levigating the progesterone powder with glycerin to form a thick paste. What type of mortar and pestle should she use to perform this step? A. Bamboo B. Wedgwood C. Porcelain D. Glass E. Stainless steel - Answer D The pharmacy technician would like to prepare an emulsion using the continental gum method (also known as the dry gum method). Place the steps below in the correct order. A. Add water all at once B. Levigate the gum with oil C. Add a quantity of water sufficient to make the final volume D. Triturate until a cracking sound is heard and the mixture looks creamy white E. Add other ingredients - Answer B, A, D, E, C Which of the following types of excipients are surfactants? A. Disintegrant B. Emulsifier C. Anti-foaming agent D. Wetting agent E. Hydrophilic solvent - Answer B, D The pharmacy technician would like to prepare an emulsion using the English gum method (also known as the wet gum method). Place the steps below in the correct order. A. Add other ingredients B. Triturate the gum with water to form a mucilage C. Add oil slowly while triturating D. Add a quantity of water sufficient to make the final volume - Answer B, C, A, D Leslie is compounding suppositories by gently heating a fatty acid base and adding in the active ingredients. This mixture is poured into a mold and allowed to cool. Which of the following statements are true about preparing suppositories? (Select ALL that apply). A. The method described is called "compression molding." B. A cold or frozen mold should not be used, or else the melted mixture can solidify too early. C. Mineral oil is a good lubricant for oil-soluble bases. D. A cold or frozen mold should not be used because it can cause cracks in the suppository. E. Glycerin is a good lubricant for water-soluble bases. - Answer B, D Which of the following statements is correct regarding the labeling, storage and stability of non-sterile compounded products? (Select ALL that apply.) A. The BUD for nonaqueous formulations is the earliest expiration date of any active pharmaceutical ingredient (API) or 12 months, whichever comes first. B. Store all bulk products off the floor and rotate the stock so that the nearest expiration date is in front and used first. C. Guidelines for handling and storing hazardous drug are provided by USP 800. D. A statement that the product has been compounded by the pharmacy must be placed on the label of the container. E. Beyond use dates (BUDs) must not be later than the expiration date on the container of any of the individual components. - Answer B, C, D, E Selena is currently gathering the equipment necessary to begin compounding mupirocin 2% cream. What is the purpose of a homogenizer? A. To weight ingredients B. To thoroughly mix ingredients C. To mold the final compounded product D To reduce the particle size of powders E. To fill capsules - Answer B A pharmacist is preparing a compounded topical gel containing glycolic acid 5%, hydroquinone 1% and tretinoin 0.025% in a cream base. Select the maximum beyond use-date that can be applied to the label: A. 7 days B. 10 days C. 14 days D. 30 days E. 6 months - Answer D In the compounding kit above, what is the purpose of sucralose? A. Lubricant B. Levigating agent C. Anti-foaming agnet D. Sweetener, natural E. Sweetener, artificial - Answer E In the compounding kit above, what is the purpose of xanthan gum? A. Thickening agent B. Levigating agent C. Coating D. Emollient base E. Antioxidant - Answer A
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