Test Bank For Introduction To Clinical Pharmacology 9th Edition By Visovsky

Test Bank For Introduction To Clinical Pharmacology 9th Edition By Visovsky Table of Contents Chapter 01: Pharmacology and the Nursing Process in LPN Practice .................................................. 2 Chapter 02: Legal, Regulatory, and Ethical Aspects of Drug Administration ......................................... 7 Chapter 03: Principles of Pharmacology ............................................................................................ 11 Chapter 04: Drug Calculation: Preparing and Giving Drugs ............................................................... 17 Chapter 05: Anti-infective Drugs: Antibacterial, Antitubercular, and Antifungal Agents ........................ 22 Chapter 06: Antivirals and Antiretrovirals ........................................................................................... 32 Chapter 07: Drugs for Allergy and Respiratory Problems ................................................................... 39 Chapter 08: Drugs Affecting the Renal/Urinary and Cardiovascular Problems .................................... 44 Chapter 09: Drug Therapy for Central Nervous System Problems ...................................................... 54 Chapter 10: Drug Therapy for Mental Health ...................................................................................... 60 Chapter 11: Drugs for Pain Management ........................................................................................... 68 Chapter 12: Anti-inflammatory, Antiarthritis, and Antigout Drugs ........................................................ 74 Chapter 13: Drugs for Gastrointestinal Problems ............................................................................... 82 Chapter 14: Drugs Affecting the Hematologic System ....................................................................... 88 Chapter 15: Drugs for Immunization and Immunomodulation ............................................................. 97 Chapter 16: Hormones and Drugs for Osteoporosis ........................................................................ 102 Chapter 17: Drug Therapy for Diabetes............................................................................................ 110 Chapter 18: Drugs for Ear and Eye Problems .................................................................................. 118 Chapter 19: Over-the-Counter Products, Herbal and Alternative Drugs, and Vitamins and Minerals .. 122 1 | P a g eChapter 01: Pharmacology and the Nursing Process in LPN Practice MULTIPLE CHOICE 1. You are assessing the skin of a newly admitted patient and note a 2 inch area of redness at the sacrum. Which type of data are you collecting with this information? a. Objective data b. Inspection c. Subjective data d. Alternative therapy ANS: A Objective data are obtained by the healthcare provider during physical examination, or that are measurable (i.e., laboratory results). DIF: Cognitive Level: Applying REF: p.3 2. Which part of the nursing process includes setting goals for the nursing care required when giving drugs to a patient? a. Assessment b. Planning c. Evaluation d. Diagnosis ANS: B The nursing process consists of five major steps in this order: assessment, diagnosis, planning, implementation, evaluation. It is in the planning step that the goals for nursing care related to drugs are set based upon data collected. DIF: Cognitive Level: Remembering REF: p.4 3. When would it be appropriate to withhold a drug instead of giving it to a patient? a. When the order is written by hand b. When any part of the drug order is unclear c. When the drug improves the patient’s symptoms d. When the order contains both the generic and trade name of the drug ANS: B You must use good judgment in carrying out a drug order. If, in your judgment, the order is unclear, or incorrect, it should be withheld (not given) until your concerns can be answered by the patient’s healthcare provider. DIF: Cognitive Level: Applying REF: p.4 4. Which action would you take to ensure that an order for a drug is accurate? a. Check the drug record with the Kardex file. b. Compare the order with the drug history. c. Compare the order to the patient’s reason for admission. d. Check the drug record with the original healthcare provider’s order. ANS: D Once the healthcare provider orders the drug, you must verify that the order is accurate. This is done by checking the drug chart or drug record with the healthcare provider’s original order. DIF: Cognitive Level: Remembering REF: p.4 2 | P a g e5. What do the nine “rights” of drug administration include? a. Right patient, drug, dose, route, time, reason, documentation, response, and right to refuse b. Right drug, diagnosis, time, patient, route, drug history, documents, and right to refuse c. Right drug, amount, route, time, nurse, reason, route, diagnosis, and documentation d. Right dose, time, healthcare provider, patient, route, documentation, response, and drug ANS: A There are nine “rights” of drug administration: you must identify the right patient, give the right drug at the right dose, right route, right time, for the right reason, using the right documentation to record that the dose has been given, monitor the patient for the right response, and note that the patient has the right to refuse a drug. DIF: Cognitive Level: Remembering REF: p.5 6. Which action should you take to ensure that you are giving a drug to the right patient? a. Verifying the drug record with the patient name on the chart b. Verifying the patient’s room and bed number with the chart c. Asking the patient to state his or her birth date and Social Security number d. Asking the patient to state their name and birth date, and then checking the patient’s identification bracelet ANS: D Before giving any drug, two forms of patient identifications should be used to identify the correct patient. Each patient should be asked his or her name, and another form of identification, such as birth date; then you should check the patient’s identification bracelet. DIF: Cognitive Level: Applying REF: p.5 7. Which category of drugs should be given exactly on schedule in order to maintain a consistent level of the drug in the body? a. Steroids b. Diuretics c. Aspirin products d. Anticoagulants ANS: D Certain drugs must be given at specific time interval (right time). Anticoagulants must be given at the same time each day to maintain a therapeutic blood level in order to prevent blood clots. DIF: Cognitive Level: Applying REF: p.7 8. Which nursing action is not appropriate when giving drugs to a patient? a. Leaving the drug at the patient’s bedside to take when he/she awakens b. Asking the patient if he or she has any allergies to drugs c. Checking a drug reference to verify the action of the drug d. Explaining to the patient the possible side effects of the drug ANS: A It is never permissible to leave drugs at the patient’s bedside. As the nurse, you are responsible for witnessing the patient taking the drug(s), or documentation of the patient’s 3 | P a g erefusal. DIF: Cognitive Level: Applying REF: p.10 9. Which of the following nursing actions is an example of evaluating patient responses to drug therapy? a. Documenting the fact that the patient refused the drug b. Making sure you have assembled all necessary equipment c. Taking the patient’s blood pressure before giving an antihypertensive d. Taking the temperature of a patient an hour after giving an antipyretic ANS: D Evaluation is the process of determining the right response of the patient to the drug given. The correct response to an antipyretic is a reduction in fever. DIF: Cognitive Level: Knowing REF: p.9 10. Which statement is considered to be an example of objective data gathered in the assessment of a patient who will be receiving drugs for the treatment of an injury? a. The patient’s skin is warm and dry to touch. b. The patient tells you “I have pain in my lower back.” c. The patient states he is having trouble catching his breath. d. The patient checks off “no history of drug allergies” on the health form. ANS: A Objective data are physical findings the nurse can see during careful inspection, palpation, percussion, and auscultation. DIF: Cognitive Level: Knowing REF: p.3 11. You are interviewing a patient to obtain a current drug history. What information should be part of this report? a. The color of each drug in pill form b. The names and dosages of each drug c. The major health conditions of the patient d. The nursing diagnoses that come from the collected information ANS: B In the interview to obtain a current and accurate drug history, the names of each drug and, if possible, the dosage of each drug are recorded. DIF: Cognitive Level: Applying REF: p.3 12. A patient you are caring for is prescribed 30 units of NPH insulin to be given subcutaneously. You know that insulin is considered a “high-alert drug.” What nursing action would you perform to give a high-alert drug safely? a. Call the healthcare provider to double check the order. b. Ensure an insulin level is drawn before giving the drug. c. Have another nurse check the order and dosage before giving it. d. Refuse to give this drug, as it can only be given by a registered nurse. ANS: C Many institutions have policies that require two nurses to double check the order and dosages of high-alert drugs to reduce the risk of error and adverse effects for the patient. This is especially important if the drug dose needs to be calculated. 4 | P a g eDIF: Cognitive Level: Applying REF: p.8 13. You are about to give the prescribed drugs to a patient in your care. When you approach the patient with the drugs, the patient refuses to take one of the drugs. What is your best action? a. Ask the pharmacy if there is a substitute drug for the one the patient refused. b. Acknowledge to patient’s right to refuse, no other action is needed. c. Let the patient know the consequences of refusing the drug. d. Notify the charge nurse or healthcare provider. ANS: D Never record drugs that were not given or record them before they are given. If a patient does not receive the drug for any reason, notify the nurse in charge or the healthcare provider according to your healthcare setting policies. DIF: Cognitive Level: Applying REF: p.8 14. You have given the antibiotic penicillin as prescribed to a patient with no reported drug allergies. Thirty minutes after receiving the drug, the patient notifies you that he/she has developed hives and swelling of the lips. What is your best first action? a. Call the pharmacy and report this as an adverse reaction to the drug. b. Immediately give epinephrine to counter the drug reaction. c. Reassure the patient that this is a typical side effect of the drug. d. Report the findings to the RN or healthcare provider and remain with the patient. ANS: D If you suspect the patient is having an adverse effect, such as an allergic reaction, report this immediately to the RN or healthcare provider. Remain with the patient, monitoring for changes in breathing or vital signs, until the RN or healthcare provider arrives with additional orders to be carried out. DIF: Cognitive Level: Applying REF: p.9 15. You are working on a very busy 35-bed hospice unit. The RN you are working with just got a new admission and hands you a syringe with “pain drug” in it. He/she asks you to give this drug to a specified patient. What is your most appropriate action? a. Assist the RN by giving the drug as requested for this one time only. b. Refuse to give a drug that is not for a patient you are assigned to care for. c. Refuse, but prepare another dose of the drug yourself, and give as prescribed. d. Assist the RN as directed, as under the RN’s supervision, this practice is permitted. ANS: C You are never to give a drug prepared by another nurse, even during a busy time or during an emergency. To meet all the patient safety standards covered by the “9 Rights,” you are required to give only drugs you have prepared. DIF: Cognitive Level: Applying REF: p.7 16. You are evaluating the response of a patient 30 minutes after receiving an antihypertensive drug. Upon assessment of the patient’s blood pressure, you note the patient has become hypotensive. What type of drug effect is this patient experiencing? a. An adverse effect of the drug b. A side effect of the drug c. A therapeutic effect of the drug d. An allergic reaction to the drug 5 | P a g eANS: A An adverse effect is seen when patients do not respond to drugs in the way they should, or develop new signs or symptoms. When a patient has an adverse effect, you should report this immediately to the RN or healthcare provider. DIF: Cognitive Level: Knowing MULTIPLE RESPONSE 1. Before giving a drug to a patient which steps should you take to ensure safe drug administration? (Select all that apply.) a. Use two forms of patient identification. b. Ask the patient about any drug allergies. c. Check the drug before removing it from the unit-dose cart. d. Check the dose before preparing or measuring the drug. e. Check the drug just before you open it and give it to the patient. f. Document the drug given before you enter into the patient’s room. ANS: A, B, C, D, E The nurse needs to use two forms of identification to ensure the drug is given to the right patient. The nurse should read the drug label at least three times: (1) before taking the drug from the unit-dose cart or shelf, (2) before preparing or measuring the prescribed dose of drug, and (3) before giving it to the patient. Asking about drug allergies is important if this information is not available, or if drugs associated with allergic reactions, such as antibiotics, are given. DIF: Cognitive Level: Applying REF: p.10 2. You are taking the drug history from a patient. Which of the following information should be collected as part of this interview? (Select all that apply.) a. Allergies to any drugs b. Alcohol or recreational drug use c. The time of day preferred for taking drugs d. The use of nutritional supplements or herbs e. The strategies you will use to care for the patient f. The illness or symptoms for which the drug is needed ANS: A, B, D, F The patient’s drug history consists of symptoms or diseases for which a drug is needed, the names, and dosages of all drugs, alcohol or recreational drug history, and alternative treatments, such as nutritional or herbal therapies. DIF: Cognitive Level: Applying REF: p.3 3. When evaluating a patient’s response to a drug, which factors should you consider? (Select all that apply.) a. The clarity of all written drug orders b. The expected side effects of the drug c. The reason the drug was prescribed d. The therapeutic effects of the drug e. The timing of the prescribed drug f. The adverse effects of the drug ANS: B, D, E The three factors to be considered in evaluating responses to drug therapy are the 6 | P a g e REF: p.9therapeutic effects, expected side effects, and adverse effects. DIF: Cognitive Level: Remembering REF: p.9 Chapter 02: Legal, Regulatory, and Ethical Aspects of Drug Administration MULTIPLE CHOICE 1. Which of the following scenarios may be a sign of possible drug diversion on a unit? a. A patient is dissatisfied with the drug administration schedule. b. A patient receiving oral antibiotics has an excess amount of pills. c. A patient is unaware that the nurse mixed a drug in applesauce. d. A patient receiving opioids reports increased pain. ANS: D Drug diversion is defined as the illegal transfer of regulated drugs (like narcotics) from the patient for whom it was prescribed, to another person, such as a nurse, for their own (or others) use. Drug diversion should also be suspected if patients continually report pain despite appropriate drug treatment, and if inaccurate narcotic counts are noted. DIF: Cognitive Level: Remembering REF: pp. 13-14 2. Which of the following is an example of psychological dependence (addiction) to a drug? a. Symptoms of drug withdrawal b. Pain, confusion, and seizures c. An intense mental desire for certain drugs d. Shaking and an increased heart rate after taking a drug ANS: C Psychological dependence, or addiction, is a mental desire associated with taking certain substances, such as cocaine or alcohol. Symptoms of mental dependence such as anxiety, anger, or depression can occur with psychological dependence. DIF: Cognitive Level: Remembering REF: p. 12 3. You have obtained a liquid narcotic for a patient in pain from the unit’s locked cabinet. However, the dose was accidentally spilled before to giving it to the patient. What is the best action to take at this point? a. Ask another nurse to cosign the inventory record describing the situation. b. Immediately obtain another dose from the narcotic control system. c. Document the occurrence in the drug record. d. Clean up the spill and notify the supervisor. ANS: A Accounting for controlled substances is a legal requirement. If the drug is accidentally dropped, contaminated, or spilled two nurses must sign the inventory report and describe the situation. DIF: Cognitive Level: Knowing REF: p. 14 4. As you arrive to work, a nurse from the previous shift tells you that she has completed the narcotic count for your shift. What action should be taken? 7 | P a g ea. There is no need for any additional action as this is the standard procedure. b. Accept the keys to the narcotic cabinet and recount the drugs yourself. c. Recount the narcotics again with a nurse from the previous shift. d. Recount the drugs yourself at the end of your shift. ANS: C At the end of each shift, the contents of the locked cabinet are counted together by one nurse from each shift in order to verify the narcotics count. If not done properly, the nurse risks being held accountable for any shortages or discrepancies, and may be found guilty of falsifying the narcotic count records. DIF: Cognitive Level: Applying REF: p. 14 5. A one-time order for a controlled substance drug has been written for a patient you are caring for. However, the drug ordered is available only in a larger dose than is needed. What should you do with the remaining drug? a. Give the full dose that is available. b. Flush the remaining drug in the toilet of the patient’s bathroom. c. Save the remaining drug in case the patient needs it again. d. Have another nurse witness the wasting of the leftover drug, and document according to policy. ANS: D If the ordered dose is smaller than the dose provided (so that some drug must be discarded), two nurses witness the wasting of the drug and sign the controlled substance inventory report according to institution policy. DIF: Cognitive Level: Knowing REF: p. 14 6. An elderly patient in an assisted living home requests an over-the-counter cough preparation for a mild couch she is experiencing. What is your best response? a. “I do not have any of this drug for you at this time, but can give you a dose from another patient’s supply.” b. “I will bring it to you right away, but I must keep it with your other prescription drugs.” c. “I will need to contact your healthcare provider for an order before I can give this drug to you.” d. “You may have this, but your family will need to bring it in for you.” ANS: C Over-the-counter (OTC) drugs do not require a prescription for purchase, but a healthcare provider’s order is required before it can be given by the LPN/LVN in an institutional setting. OTC drugs may interact with a patient’s prescribed drugs, especially in the elderly. DIF: Cognitive Level: Applying REF: p. 15 7. Which of the following orders is an example of a single drug order? a. Atenolol 50 mg orally daily b. Morphine sulfate 4 mg IV stat c. Cefazolin 1 g IV 8 a.m. before surgery d. Tramadol 50 mg orally as needed for pain ANS: C A single drug order is a drug that is scheduled to be given at a specified time for one dose 8 | P a g eonly. DIF: Cognitive Level: Knowing REF: p. 16 8. Diphenhydramine 50 mg IV push is ordered by the healthcare provider to be given “stat.” When should this drug be given? a. Immediately b. As need upon the patient’s request c. Within one hour of receiving the order d. When you have completed giving the oral drugs first ANS: A A stat order is a type of drug order that is to be given immediately. DIF: Cognitive Level: Knowing REF: p. 16 9. You are giving drugs to the patients assigned to you when you realize that you gave a drug to the wrong patient. What action should you take? a. Evaluate the patient’s condition and notify the healthcare provider. b. Submit a report only if the patient has an adverse reaction. c. Inform the patient and complete an incident report. d. Document the occurrence in the patient record. ANS: A When it is discovered that an error has been made, you should immediately evaluate the patient for any adverse reactions and notify the healthcare provider as soon as possible. An incident report should be completed and the supervisor notified. DIF: Cognitive Level: Applying MULTIPLE RESPONSE 1. Which of the following drugs is considered a high-alert drug? (Select all that apply.) a. Percocet b. Insulin c. Heparin d. Herceptin e. Potassium f. Indomethacin ANS: B, C, E Categories of common high-alert drugs can be remembered using the acronym “PINCH.” P is for potassium, I is for insulin, N is for narcotics (opioids), C is for cancer chemotherapy drugs, and H is for heparin or any drug type that interferes with blood clotting. DIF: Cognitive Level: Remembering REF: p. 19 2. Which of the following actions should you take before you give a drug mixed into food or the mixing of drugs with food or drink must be documented in the patients care plan, and on the drug administration chart to address the legal aspects of this practice a drink? (Select all that apply.) a. Check a drug handbook. b. Inform the patient or family. 9 | P a g e REF: p. 19c. Inform the healthcare provider. d. Thoroughly crush pills with an enteric coating. e. Document the mixing of drugs in food or drink in the chart. f. Give the prescribed drug mixed in food during a regular patient meal. ANS: A, B, C, E Covert drug administration is discouraged. Therefore, nurses are under obligation to inform the healthcare provider, who ordered the drug, and the patient or family. Some drugs may not be mixed with certain foods or drinks, or may not be crushed, so checking the drug handbook is a necessary step to ensure patient safety. The mixing of drugs with food or drink must be documented in the patients care plan, and on the drug administration chart to address the legal aspects of this practice. DIF: Cognitive Level: Applying REF: p. 12 3. Which steps should you take to identify possible drug errors in a patient’s drug orders? (Select all that apply.) a. Call the pharmacy. b. Clarify anything that is unreadable c. Ask the patient about the drug. d. Reconcile the drug list with an old drug record. e. Clarify vague orders with the healthcare provider. f. Check the original written order with the healthcare provider. ANS: A, B, E, F Checking with a reliable source, such as the pharmacist, clarifying vague orders or anything that is difficult to read (if handwritten) and checking the original written order are all ways to avoid drug errors. DIF: Cognitive Level: Applying REF: p. 17 4. Which levels of regulation must you adhere to when giving drugs to a patient? (Select all that apply.) a. City Regulations b. State Regulations c. County Regulations d. Federal Regulations e. Institutional Regulations f. Health Insurance Regulations ANS: B, D, E Nurses who are responsible for giving drugs to patients in their care have three levels of regulations to follow: federal (describes and controls), state (regulates who dispenses), and individual hospital or agency (additional guidelines or policies). DIF: Cognitive Level: Remembering REF: pp. 14-16 5. A narcotic control system is used in any hospital or agency. Which of the following are special regulations applied for control of narcotics that you must follow? (Select all that apply.) a. Narcotics are stored in a special locked cabinet. b. Narcotic control is the responsibility of everyone on the unit. c. Narcotics may be borrowed from patient to patient for emergency use. d. You may return unused narcotics to the patient’s family upon discharge. 10 | P a g ee. You are responsible for signing out every narcotic drug used for a patient. f. An inventory of the narcotics on a unit must be kept and verified by two nurses. ANS: A, E, F Narcotics are stored in special, limited-access, locked cabinets. A nurse records all controlled substance drug during the shift. The inventory report form is completed before the drug is removed from the cabinet. DIF: Cognitive Level: Applying REF: pp. 12-13 6. A discrepancy in the narcotics inventory for morphine 5 mg/mL vials is discovered when the narcotics count is performed. The count is short by one vial. Which of the following steps should you take to reconcile the count? (Select all that apply.) a. No action needs to be taken for small discrepancies. b. Notify the nursing supervisor and the pharmacy of the discrepancy. c. Identify if any nurse forgot to record any of the narcotics removed. d. Ask only the nurses who used narcotics about the drugs they have given. e. Check drug records to reconcile if narcotics given and not signed for. f. Notify the security department of the institution if drug diversion is suspected. ANS: B, C, E, F All nurses must be asked about narcotics that may have been given. Steps must be retraced to see if someone forgot to record any drug. Patient charts might also be checked to see if drug was given that was not signed for on the inventory report. If errors in the report cannot be found, both the pharmacy and the nursing service office must be notified. If drug diversion is suspected, the hospital administrator and security police are usually contacted. DIF: Cognitive Level: Applying REF: pp. 12-14 Chapter 03: Principles of Pharmacology MULTIPLE CHOICE 1. Which is always true regarding the generic name for a drug? a. It is the same in any country. b. It is capitalized when written. c. It is similar to the chemical name. d. It is assigned by a specific manufacturer. ANS: A The generic name is the common drug name used. This name is the same in all countries. The generic drug name is written in lower-case letters, whereas the trade name or brand name of a drug is capitalized. DIF: Cognitive Level: Remembering REF: p.23 2. What is the difference between the generic and the trade names of drugs? a. The generic name is approved and owned by the Federal Drug 11 | P a g eStandards Committee. b. The generic name represents the proprietary name given by a drug company. c. The trade name is one that is registered to a specific drug manufacturer. d. The trade name, or chemical name, represents the chemicals in the drug. ANS: C The trade name is the proprietary or brand name for the drug, and is registered to a specific drug company. DIF: Cognitive Level: Remembering REF: p.23 3. Which statement is true about the way drugs and receptor sites work? a. The drug attaches to a receptor site and activates it. b. The drug prevents activation of the receptor site. c. The receptor site is activated, allowing DNA replication to occur. d. The receptor sites are activated once the drug leaves the receptor site. ANS: A The drug attaches to the receptor site and activates the receptor. DIF: Cognitive Level: Knowing REF: p.23 4. What response would you expect in a patient given a drug that is considered an antagonist? a. Positive and negative activation of cell receptors b. A complete activation of cell receptors c. A partial activation of cell receptors d. No activation of cell receptors ANS: D When a drug attaches at a drug receptor site but does not activate or unlock it, there is no increase in cell activity and the drug is an antagonist. DIF: Cognitive Level: Knowing REF: p.24 5. A patient is given a drug that is a known agonist. How would you expect this drug to work? a. This drug works by attaching to the receptor site to activate it. b. This drug works by deactivation of all cellular receptor sites. c. This drug works to partially block receptor sites. d. This drug works by interacting with other drugs. ANS: A A drug agonist works by activating or unlocking receptors, and has the same actions as the body’s own chemicals. DIF: Cognitive Level: Knowing REF: p.24 6. You are giving an oral drug to a patient. For this drug to be utilized by the body, which mechanism is the first to be involved in that process? a. Excretion b. Absorption c. Metabolism d. Distribution ANS: B Absorption involves the way a drug enters the body and passes into the body and tissues. Drug absorption is the first step and it takes place through the processes of diffusion, filtration, 12 | P a g eand osmosis. DIF: Cognitive Level: Knowing REF: p.24 7. You are giving an oral drug to a patient who asks you to explain the reason for taking water with a tablet. What is your best response? a. “Water is important for proper metabolism.” b. “Juice or milk can keep it from dissolving.” c. “Water helps to dissolve the drug.” d. “Water keeps the drug potent.” ANS: C All drugs must be dissolved in body fluid before they enter body tissues. When the patient takes water with a tablet, it not only helps in swallowing but also helps dissolve the drug and increase its solubility. DIF: Cognitive Level: Understanding REF: p.24 8. Which drug route would you expect to be the most rapidly absorbed? a. Subcutaneous injection b. Intravenous injection c. Rectal suppository d. Sublingual tablet ANS: B Drugs injected intravenously into the bloodstream have the fastest action. DIF: Cognitive Level: Remembering REF: p.24 9. What is the process by which molecules move from a region of higher concentration to one of lower concentration? a. Diffusion b. Osmosis c. Filtration d. Solubility ANS: A In diffusion, molecules move from a region of higher concentration to one of lower concentration. DIF: Cognitive Level: Remembering REF: p.25 10. A 62-year-old male patient with liver disease asks you why he is receiving a drug intravenously rather than by mouth. What is your best response? a. “Many oral drugs are inactivated as you get older.” b. “Your liver disease impairs the transformation of a drug into its active form.” c. “Intravenous drugs reduce toxicity to the liver through first-pass metabolism.” d. “Individuals with liver disease have a genetic impairment that prevents drug activation.” ANS: B Many drugs must be activated by enzymes before they can be used in the body. This biotransformation happens in the liver. Liver disease impairs this process. DIF: Cognitive Level: Applying 13 | P a g e REF: pp.25-2611. A patient who is beginning a new cholesterol-lowering drug tells you he plans to take this drug in the evening with his usual glass of grapefruit juice. What is your best response? a. “The vitamin C in grapefruit juice enhances the action of cholesterol-lowering drugs.” b. “The acid environment of grapefruit juice promotes drug metabolism.” c. “Taking grapefruit juice can reduce the effectiveness of the drug.” d. “Taking grapefruit juice can increase the absorption of the drug.” ANS: C Grapefruit juice affects (usually reduces) the absorption of many drugs such as antihistamines, cholesterol-lowering drugs, HIV drugs, and transplant drugs. DIF: Cognitive Level: Applying REF: p.26 12. You give a patient 400 mg of an oral drug at noon. This drug has a half-life of 2h. At what time will 100 mg remain? a. 2:00p.m. b. 6:00p.m. c. 8:00p.m. d. 4:00p.m. ANS: D With a half-life of 2h, the amount of drug remaining in the blood decreases by 50% every 2h. So, when 400 mg are given at noon, by 2:00p.m., 200 mg remain; by 4:00p.m., 100 mg remain. DIF: Cognitive Level: Understanding REF: p.26 13. When teaching a patient about a new drug that has been prescribed, the patient asks you to explain the difference between a side effect and an adverse reaction. What is your best response? a. Both side effects and adverse reactions are mild. b. Both side effects and adverse reactions are severe. c. Side effects are mild, and adverse effects are severe. d. Side effects are severe, and adverse reactions are mild. ANS: C Side effects are usually seen as mild but annoying responses to a drug. Adverse reactions, or adverse effects, usually imply more severe symptoms or problems that develop because of the drug. DIF: Cognitive Level: Applying REF: p.27 14. A patient tells you that she is experiencing sleepiness after taking a drug prescribed for back pain. What is your best response? a. “You are having a severe drug interaction.” b. “You are having an expected drug side effect.” c. “You are having the desired effect of this drug.” d. “You are having an idiosyncratic response to this drug”. ANS: B Drugs may influence many body systems at the same time, so the effect of the drug is often not restricted to the desired action. Side effects are usually seen as mild but annoying responses to the drug. In the case of many drugs for pain, sleepiness is an expected side effect. 14 | P a g eDIF: Cognitive Level: Applying REF: p.27 15. A patient who was given intravenous penicillin for a severe infection develops hives, itching, and facial swelling immediately after the infusion. What type of drug reaction is this patient experiencing? a. An adverse reaction b. A paradoxical reaction c. An anaphylactic reaction d. A hypersensitivity reaction ANS: D Some drugs (sulfa products, aspirin, and penicillin) can produce allergic (hypersensitivity) reactions that usually occur when an individual has taken the drug and the body has developed antibodies to it. DIF: Cognitive Level: Knowing REF: p.27 16. What information should be included in the teaching plan for a young woman who has begun on a 10-day course of oral antibiotic therapy for an infection? a. Antibiotics can mask the signs of allergic reactions. b. Antibiotics interfere with P-450 enzyme pathways in women. c. Antibiotics can have a synergistic effect when given with opiates. d. Antibiotics interact with birth control pills making them less effective. ANS: D Drug interactions can produce adverse effects. Many antibiotics make birth control tablets less effective, thus making it more likely that a woman will get pregnant while taking both drugs if she is sexually active. DIF: Cognitive Level: Applying REF: p.28 17. Probenecid is sometimes given to patients taking penicillin to increase the amount of penicillin absorbed. Which effect is this an example of? a. Additive effect b. Drug interaction c. Synergistic effect d. Antagonistic effect ANS: A Some drugs are given together on purpose to produce an additive effect that is helpful in increasing the levels of penicillin in the blood. Probenecid does this by blocking penicillin’s elimination pathway via the kidneys (by inhibiting renal tubular secretion). Maintaining high blood levels of penicillin is important in treating severe infections. DIF: Cognitive Level: Knowing REF: p.28 18. A patient has been prescribed an antianxiety drug to be taken in the evening. He tells you he has 2 to 3 beers with dinner each night. What is your best response? a. “The effect of alcohol on this drug is not a concern.” b. “Limit your alcohol use to 8 ounces a day with a meal.” c. “Eating a full meal before taking the drug will negate any side effects.” d. “Drinking any alcohol with this drug can have a harmful additive effect.” ANS: D When taken together with alcohol, drugs such as antianxiety agents can result in an 15 | P a g eadditive effect. DIF: Cognitive Level: Applying REF: p.28 19. You are caring for a patient with liver failure who will be starting on an anticoagulant for the treatment of a deep vein thrombosis. What effect of this drug should you expect? a. The effect of the anticoagulant will be prolonged and pose a risk for bleeding. b. The effect of the anticoagulant will be reduced, requiring additional doses. c. The effect of the anticoagulant will result in an increased risk for infection. d. There will be no effect of the anticoagulant on the deep vein thrombosis. ANS: A A patient with liver or the kidney disease will retain a drug much longer, increasing the risk for adverse and toxic effects. In the case of an anticoagulant, the risk for bleeding is increased in a patient with liver disease. DIF: Cognitive Level: Applying REF: p.29 20. Which statement concerning absorption of oral drugs is true for neonates? a. Oral prodrugs are activated most quickly in the neonate. b. Oral drugs are poorly absorbed for the gastrointestinal tract of the neonate. c. The overall low body metabolism results in increased toxicity in the neonate. d. The high percentage of total body water rapidly dilutes oral drugs in the neonate. ANS: B In neonates oral drugs are absorbed poorly from the GI tract because no gastric acid is present to help breakdown drugs, no intestinal bacteria or enzyme function is present to metabolize a drug, and the time it takes for a drug to move through the stomach and intestines is slow. DIF: Cognitive Level: Knowing MULTIPLE RESPONSE 1. Which of the following factors are known to influence drug distribution? (Select all that apply.) a. Tissue type b. Drug binding c. Tissue perfusion d. Receptor site binding e. Electron displacement f. Cell membrane penetration ANS: A, B, C, F Distribution of the drug depends upon tissue (perfusion), types of tissue (bone, fat, and muscle) and how easy it is for the drug to penetrate the cell membranes. Some drugs will also bind together with many blood substances and proteins such as albumin. This binding allows only “free” drug (that which is not bound) to penetrate the tissues. DIF: Cognitive Level: Remembering REF: p.30 2. Which of the following routes are sites of excretion of drug metabolites from the body? (Select all that apply.) a. Feces b. Urine 16 | P a g e REF: p.30c. Breast milk d. Bloodstream e. Lymph nodes f. Salivary glands ANS: A, B, C All inactive chemicals, chemical by-products, and waste (metabolites) finally breakdown through metabolism and are removed from the body through the process of excretion in feces, urine, and breast milk. DIF: Cognitive Level: Knowing REF: pp.31-32 3. What are the possible responses a patient can have to a drug’s actions? (Select all that apply.) a. Desired action b. Bioequivalence c. Adverse effects d. Side effects e. Half-life f. Onset ANS: A, C, D When a drug is given to a patient, the expected response of the drug is called the desired action. Other responses to drugs include side effects and adverse effects. DIF: Cognitive Level: Applying REF: p.27 4. Which of the following issues related to drug therapy in the older patient are true? (Select all that apply.) a. Drugs are secreted more slowly in older patients. b. Drug interactions are far less prevalent in older patients. c. Adverse drug reactions are more common in older patients. d. Dehydration can cause the blood level of drug to increase in older patients. e. Fat-soluble drugs are eliminated, and leave the body quickly in older patients. f. Loss of electrolytes due to diuretics can result in loss of electrolytes in older patients. ANS: A, C, D, F Drugs are absorbed, metabolized, and excreted more slowly and less completely in older adults. Adverse drug reactions (ADRs) are common in older adults. Issues such as falls, hypotension, delirium, kidney failure, and bleeding are common clinical manifestations. Older adult patients may become dehydrated easily, thus allowing the amount of drug in the blood to increase. Diuretics lead to an increase in urination and this can lead to loss of electrolytes. DIF: Cognitive Level: Knowing REF: p.30 Chapter 04: Drug Calculation: Preparing and Giving Drugs MULTIPLE CHOICE 1. Which of the following is an example of a drug given in units instead of milligrams? a. Insulin b. Furosemide 17 | P a g ec. Normal saline d. Nitroglycerine ANS: A Insulin is a parenteral drug that is given in units, not milligrams. Insulin is drawn up using a unit-based syringe DIF: Cognitive Level: Remembering REF: p.37 2. When calculating the dose of a drug to be given to a child, Clark’s rule is used. What measure is Clark’s rule based upon? a. The age of the child b. The weight of the child c. One-half of the adult dose d. The international standardized ratio ANS: B The Joint Commission now recommends that all dosages for children be weight- based. Clark’s rule: Pediatric child dose=(weight of child/150 lbs x adultdose). DIF: Cognitive Level: Remembering REF: p.39 3. Which statement is true regarding giving drugs by the IV route? a. Intravenous drugs must go through first-pass metabolism to be absorbed. b. Intravenous drugs are deposited directly into the bloodstream. c. Intravenous drugs have lower rates of adverse events. d. Intravenous drugs are less effective than oral drugs. ANS: B Drugs administered by the intravenous route are deposited directly into the bloodstream and have a higher incidence of chance for adverse events. DIF: Cognitive Level: Knowing REF: p.39 4. Which represents the proper way to give an oral capsule? a. Crush and dilute it in warm water. b. Tell the patient to swallow it whole. c. Tell the patient to chew it completely. d. Pierce it with a needle and squeeze into the mouth. ANS: B Remain at the patient’s bedside until the drug is swallowed. Do not crush tablets or break capsules without checking with the pharmacist. Many drugs have special coatings that are essential for proper absorption. DIF: Cognitive Level: Knowing REF: p.41 5. An elderly patient is scheduled to take six drugs each morning. What action should you take when giving these drugs? a. Allow extra time to give all of the drugs. b. Crush all the drugs before giving them. c. Allow the patient to take only the drugs she can swallow. d. Leave the drugs at the bedside so the patient can take them slowly. ANS: A 18 | P a g eAllow extra time to give drug to the elderly. These individuals often are slower at swallowing drugs and water. The nurse must be present for the administration of every drug. DIF: Cognitive Level: Applying REF