The 1918 Spanish Flu Pandemic, the Origins of the H1N1-virus Strain, a Glance in History

The majority of all human infectious diseases and pandemics have originated through the cross-species transmission of microorganisms from animals to humans, and vice versa. The influenza A virus, eloquently illustrated how our global interconnectedness can affect the worldwide distribution of a new virus, or virus strain, one that may otherwise have remained a regional phenomena in an era before the globalized world [1]. A thorough reopening of the history archives will demonstrate the fact that most of the worldwide spread pandemics had their point zero in the continental Asia, and Africa from where they had spread to rest of the world. The three great plague pandemics had different geographic origins and paths of spread. The Justinian Plague of the 541 AD, started in central Africa and spread to Egypt and the Mediterranean. The Black Death of the 1347