RX Prep Key Drugs (with Accurate Solutions)

CYP Inducers correct answers *P*henytoin *S*moking *P*henobarbital *O*xcarbazepine *R*ifmapin (rifabutin, rifapentine) *C*arbamazepine *S*t. John's Wort *PS PORCS CYP Inhibitors correct answers *G*rapefruit *P*rotease inhibitors *A*zole antifungals *C*yclosporine, cimeditine, cobicistat *M*acrolides (claithromycin and erythromycin) *A*miodarone (dronedarone) *N*on-DHP CCBs (diltiazem and verapamil) *GPACMAN carbamazepine therapeutic range correct answers 4-12 mcg/ml digoxin therapeutic range correct answers 0.8-2 ng/ml (Afib) 0.5-0.9 ng/ml (HF) gentamicin traditional dosing therapeutic range correct answers peak: 5-10 mcg/ml trough: <2mcg/ml lithium therapeutic range correct answers 0.6-1.2 mEq/L total phenytoin/fosphenytoin therapeutic range correct answers 10-20 mcg/ml free phenytoin therapeutic range correct answers 1-2.5 mcg/ml procainamide therapeutic range correct answers 4-10 mcg/ml theophylline therapeutic range correct answers 5-15 mcg/ml tobramycin traditional dosing therapeutic range correct answers peak: 5-10 mcg/ml trough: <2 mcg/ml valproic acid therapeutic range correct answers 50-100 mcg/ml vancomycin therapeutic range correct answers trough: 15-20 for most serious infections