LYMPHOMA
LYMPHOID MALIGNANCIES
NON-HODGKIN LYMPHOMA HODGKIN OTHER
LYMPHOMA
B CELL T CELL PLASMA CELLS
NEOPLASMS NEOPLASMS
PRECURSOR PRECURSOR 1. Nodular 1. Multiple
1. B lymphoblastic 1. T lymphoblastic lymphocyte myeloma
leukaemia/ leukaemia/ predominant
lymphoma lymphoma hodgkin lymphoma
MATURE MATURE
(PERIPHERAL B (PERIPHERAL T 2. Classical Hodgkin
CELL) CELL) lymphoma
2. B cell/ Chronic 2. Adult T cell
lymphocytic lymphoma - Nodular sclerotic
Leukaemia / Small 3. Mycosis - Mixed cellularity
cell Lymphocytic Fungoides/ Sezary - Lymphocyte
lymphoma syndrome depleted
3. Follicular 4. T cell lymphoma - Lymphocyte rich
lymphoma 5. Anaplastic large
4. Mantle cell cell lymphoma
lymphoma
5. Diffuse Large B-
cell lymphoma
7. Burkitt’s
lymphoma
1. MULTIPLE MYELOMA
Monoclonal proliferation of abnormal plasma cells with infiltration of the bone
marrow & other sites
Epidemiology
- Elderly
- Males > females
- ↑ in HIV
- ↑ in chronic infection d/t chronic stimulation of IL-6 → ↑ Plasma cell differentiation
Pathogenesis
LYMPHOID MALIGNANCIES
NON-HODGKIN LYMPHOMA HODGKIN OTHER
LYMPHOMA
B CELL T CELL PLASMA CELLS
NEOPLASMS NEOPLASMS
PRECURSOR PRECURSOR 1. Nodular 1. Multiple
1. B lymphoblastic 1. T lymphoblastic lymphocyte myeloma
leukaemia/ leukaemia/ predominant
lymphoma lymphoma hodgkin lymphoma
MATURE MATURE
(PERIPHERAL B (PERIPHERAL T 2. Classical Hodgkin
CELL) CELL) lymphoma
2. B cell/ Chronic 2. Adult T cell
lymphocytic lymphoma - Nodular sclerotic
Leukaemia / Small 3. Mycosis - Mixed cellularity
cell Lymphocytic Fungoides/ Sezary - Lymphocyte
lymphoma syndrome depleted
3. Follicular 4. T cell lymphoma - Lymphocyte rich
lymphoma 5. Anaplastic large
4. Mantle cell cell lymphoma
lymphoma
5. Diffuse Large B-
cell lymphoma
7. Burkitt’s
lymphoma
1. MULTIPLE MYELOMA
Monoclonal proliferation of abnormal plasma cells with infiltration of the bone
marrow & other sites
Epidemiology
- Elderly
- Males > females
- ↑ in HIV
- ↑ in chronic infection d/t chronic stimulation of IL-6 → ↑ Plasma cell differentiation
Pathogenesis