Pharmacology Proctored Study Guide 2019

Chapter 1: Pharmacokinetics and Routes of Administration • Absorption  Route of admin affects the rate and amount of absorption o Oral:  GI pH and emptying time  Presence of food in the stomach or intestines  Form of meds (liquid/XR) o Sublingual/buccal  Quick absorption systemically through highly vascular mucous membranes o Inhalation via mouth/nose  Rapid absorption through alveolar capillary networks o Intradermal, topical  Slow, gradual absorption o SQ/IM  Highly soluble meds have rapid absorption (10-30min), poorly soluble have slower absorption  Blood perfusion at site of injection affect absorption o IV  Immediate and complete • Distribution o Transportation of meds to sites of action by body fluids o Plasma binding protein: meds compete for protein binding sites within bloodstream, primarily albumin. The ability of med to bind to protein can affect how much med will leave and travel to target tissues.