NR 546 / NR546 Actual Final Exam
2023 Prediction 70 questions (All
correct answers, Already graded A)
Which of the following is considered the pleasure center of the brain?
A. Cortico-striatal-thalamic-cortical loop
B. Mesolimbic dopamine pathway
C. Mesocortical dopamine pathway
D. None of the above - ANSWER B. Mesolimbic dopamine
pathway
The reactive reward system signals the immediate prospect of pleasure or pain
and triggers drug-seeking behavior.
A. True
B. False - ANSWER A. True
What role does the amygdala play in substance abuse?
A. Releases phasic bursts of dopamine to the nucleus accumbens when drugs of
abuse are present
B. Communicates to the ventral tegmental area when cues related to drugs of
abuse are present
C. Site of binding for most drugs of abuse
D. A and B
,E. A, B, and C - ANSWER B. Communicates to the ventral
tegmental area when cues related to drugs of abuse are present
A 45-year-old patient has tried unsuccessfully to quit smoking several times over
the past ten years. Nicotine's actions at which receptors are considered primarily
responsible for its reinforcing effects?
A. Alpha 4 beta 2 postsynaptic receptors in the ventral tegmental area
B. Alpha 7 postsynaptic receptors in the prefrontal cortex C. A and B
D. Neither A nor B - ANSWER A. Alpha 4 beta 2 postsynaptic
receptors in the ventral tegmental area
Patrick is a 22-year-old male who recently experienced a psychotic-like episode
after trying MDMA ("ecstasy") while at a party. A key binding site for
hallucinogens is the:
A. GABA-A receptor
B. Cannabinoid 1 receptor
C. Serotonin 2A receptor
D. Serotonin 2C receptor - ANSWER C. Serotonin 2A receptor
An example of volume neurotransmission is: A. Dopamine in the prefrontal cortex
B. Dopamine in the striatum
C. Norepinephrine in the prefrontal cortex
D. Norepinephrine in the striatum - ANSWER Dopamine in the
prefrontal cortex
, What is constitutive activity?
A. Signal transduction when an agonist is bound to the receptor
B. Signal transduction when an antagonist to the receptor C. Signal transudction
when an inverse agonist is bound to the receptor
D. Signal transduction when no agonist or inverse agonist is bound to the recep -
ANSWER D. Signal transduction when no agonist or inverse agonist
is bound to the recep
A partial agonist has what effect on neurotransmission?
A. Net agonism when neurotransmission is deficient
B. Net antagonism when neurotransmission is excessive
C. A and B
D. Neither A nor B
C. A and B - ANSWER C. A and B
receptor with four transmembrane regions changes conformation as GABA binds.
Which system is this process describing?
A. Presynaptic transporter
B. Ligand-gated ion channel
C. Voltage-sensitive ion chan - ANSWER B. Ligand-gated ion
channel
2023 Prediction 70 questions (All
correct answers, Already graded A)
Which of the following is considered the pleasure center of the brain?
A. Cortico-striatal-thalamic-cortical loop
B. Mesolimbic dopamine pathway
C. Mesocortical dopamine pathway
D. None of the above - ANSWER B. Mesolimbic dopamine
pathway
The reactive reward system signals the immediate prospect of pleasure or pain
and triggers drug-seeking behavior.
A. True
B. False - ANSWER A. True
What role does the amygdala play in substance abuse?
A. Releases phasic bursts of dopamine to the nucleus accumbens when drugs of
abuse are present
B. Communicates to the ventral tegmental area when cues related to drugs of
abuse are present
C. Site of binding for most drugs of abuse
D. A and B
,E. A, B, and C - ANSWER B. Communicates to the ventral
tegmental area when cues related to drugs of abuse are present
A 45-year-old patient has tried unsuccessfully to quit smoking several times over
the past ten years. Nicotine's actions at which receptors are considered primarily
responsible for its reinforcing effects?
A. Alpha 4 beta 2 postsynaptic receptors in the ventral tegmental area
B. Alpha 7 postsynaptic receptors in the prefrontal cortex C. A and B
D. Neither A nor B - ANSWER A. Alpha 4 beta 2 postsynaptic
receptors in the ventral tegmental area
Patrick is a 22-year-old male who recently experienced a psychotic-like episode
after trying MDMA ("ecstasy") while at a party. A key binding site for
hallucinogens is the:
A. GABA-A receptor
B. Cannabinoid 1 receptor
C. Serotonin 2A receptor
D. Serotonin 2C receptor - ANSWER C. Serotonin 2A receptor
An example of volume neurotransmission is: A. Dopamine in the prefrontal cortex
B. Dopamine in the striatum
C. Norepinephrine in the prefrontal cortex
D. Norepinephrine in the striatum - ANSWER Dopamine in the
prefrontal cortex
, What is constitutive activity?
A. Signal transduction when an agonist is bound to the receptor
B. Signal transduction when an antagonist to the receptor C. Signal transudction
when an inverse agonist is bound to the receptor
D. Signal transduction when no agonist or inverse agonist is bound to the recep -
ANSWER D. Signal transduction when no agonist or inverse agonist
is bound to the recep
A partial agonist has what effect on neurotransmission?
A. Net agonism when neurotransmission is deficient
B. Net antagonism when neurotransmission is excessive
C. A and B
D. Neither A nor B
C. A and B - ANSWER C. A and B
receptor with four transmembrane regions changes conformation as GABA binds.
Which system is this process describing?
A. Presynaptic transporter
B. Ligand-gated ion channel
C. Voltage-sensitive ion chan - ANSWER B. Ligand-gated ion
channel
